The Four Worst Wrinkle Fighters

What does work on wrinkles (other than a trip to a plastic surgeon)?

Dermatologists recommend creams containing tretinoin, marketed as Retin A or Renova and available only by prescription, or the weaker over-the-counter creams containing retinol. "If I had to choose one cream, I'd choose one that contains tretinoin or retinol," says Weinkle. Dermatologists also recommend creams with high concentrations of alpha hydroxyl acid, which exfoliate dead skin and trigger formation of new collagen and elastic fibers. OTC versions have a concentration of 6 percent or less of alpha hydroxyl acid, while prescription products typically contain 12 percent or more.

Other helpful creams are those that contain Vitamin C and the brand formulations TNS Recovery Complex, Citrus CRS, Revaleskin and Prevage. Creams based on the small chains of amino acids called peptides seem to have some benefit in promoting collagen production, says Chicago dermatologist Carolyn Jacob, but the proof so far only comes from lab experiments, not large clinical trials with people.

And then there's prevention: Ultraviolet A rays (UVA, not UVB) are most responsible for skin aging, so check your sunscreen for UVA blockage, and opt for 30 SPF in sunny climates, says Weinkle. Sleeping on your back, rather than your stomach and side, can help prevent creases in your face.

Weinkle's personal skin care routine: She uses an at-home microdermabrasion scrub along with the Clarisonic supersonic skin brush. Microdermabrasion goes further than exfoliation, buffing away so much skin that your body reacts as if to a wound and creates brand new skin. Or try an at-home machine that uses crystals instead of the diamond head used in the most state-of-the art equipment in dermatologists' offices.

For more on wrinkle fighting techniques check out: " Secrets for Youthful Skin "
And for tips on choosing a moisturizer, check out: " Are Expensive Skin Creams Better Than Drug Store Brands? "

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