HEALTH FOR LIFE

Your Lifestyle, Your Genes and Cancer

New research explores the complex interactions that cause our most dreaded disease. A look into some of the steps you can take to reduce your risk.

 

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We've known for a long time that a high-fat diet, obesity and lack of exercise can increase the risk of developing heart disease and type 2 diabetes, two conditions that affect millions of Americans. What we are finding out now is that those same lifestyle factors also play an important role in cancer. That's the bad news. The good news is that you can do something about your lifestyle. If we grew thinner, exercised regularly, avoided diets rich in red meat (substituting poultry, fish or vegetable sources of protein) and ate diets rich in fruits and vegetables, and stopped using tobacco, we would prevent 70 percent of all cancers.

The strongest evidence of the importance of lifestyle in cancer is that most common cancers arise at dramatically different rates in different parts of the globe. Several cancers that are extremely common in the United States—colon, prostate and breast cancer—are relatively rare in other parts of the world, occurring only 1/10th or 1/20th as often. Equally striking, when people migrate from other parts of the world to the United States, within a generation their cancer rates approach those of us whose families have lived in this country for a long time. Even if people in other parts of the world stay put, but adopt a U.S. lifestyle, their risk of cancer rises; as Japanese have embraced Western habits, their rates of colon, breast and prostate cancer have skyrocketed.

What is it about our lifestyle that raises the risk of many types of cancer? The main culprits seem to be the Western diet, obesity and physical inactivity. While we've known about the importance of tobacco and cancer for more than 50 years, we are just beginning to understand how diet, a healthy body weight and regular exercise can protect us against cancer.

A striking example of the profound influence of diet was reported last summer in The Journal of the American Medical Association. Doctors determined the eating habits of patients with colon cancer in the years following surgical removal of the cancer. Over the next five years, those who ate a traditional Western diet had a threefold greater likelihood of developing a recurrence of the disease than did those who ate a "prudent" diet rich in fruits and vegetables and including only small amounts of red meat. How had diet affected these patients? The surgery clearly had not removed all their colon-cancer cells: prior to the surgery, some cells had already spread from the primary tumor. The Western diet had somehow stimulated the growth of these small deposits of residual cancer cells.

Obesity is the second most important factor in causing cancer in Western populations after tobacco, and there is evidence that maintaining a healthy weight is protective against the disease. A study by the American Cancer Society in 2003 found that the heaviest people, in comparison with the leanest, had a significantly increased risk of death from 10 different kinds of cancer in men, and from 12 different kinds in women. The most extreme examples were liver cancer in men (nearly fivefold increased risk) and uterine cancer in women (more than sixfold increased risk).

Exercise has also been shown to play an important role in protecting against some cancers. For example, the Nurses' Health Study reported that women who had one or more hours per day of moderate exercise had a 30 percent lower risk of colon cancer than women who exercised less. Exercise protects against breast cancer, as well.

Lifestyle influences a person's risk for cancer by generating growth-promoting signals that affect cells primed to become cancerous, or that already are cancerous. What primes those cells to become cancerous in the first place are changes in their genes.

All tumors begin with one renegade cell. Initially the cell is just one of about 30 trillion or so in the body. It looks no different from the cells around it, and, like those cells, it divides only if the organ it's part of needs it to divide. Then, even though the organ around it has enough cells, the renegade cell begins to multiply uncontrollably: one cell becomes two, two become four, four become eight, until the descendants are beyond counting.

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Member Comments

  • Posted By: JayDub @ 08/05/2008 11:36:48 PM

    Look at this logically. First, my wife, father, uncle, grandmother, grandfather and several cousins had forms of cancer. Some of them lead "clean" lives. Some didn't, and the source of cancer was clear; my father smoked a lot and got lung cancer. I've had to do a lot of research, and have had many conversations with doctors and specialists. But, I am not an "expert".
    However, a few things are undeniably clear. First, we live in a kind of toxic soup; an environment and set of influences we've never historically experienced before. The air, soil, food sources, fertilizers, medications and the science of growing food are all different. And so is the way we process our food. Mix that with genetic tendencies and we have a complex set of interrelated circumstances in which cancer can better find fuel.
    The quote in the article "...just beginning to understand how diet, a healthy body weight and regular exercise can protect us against cancer" is shocking. Don't these things make sense for our general well-being, regardless of cancer? Haven't they always contributed to quality of life, regardless of age or location?
    My wife is completing her radiation for cancer and is doing, thankfully, quite well. What we experienced consistently, though, is an institutional ignorance of how these true fundamentals ??? diet, weight, exercise ??? can affect acquiring, and banishing, the disease. Even the "nutritionists" they sent in were clueless.
    No, you don't have to stop eating red meat or sugar, but you DO have to moderate intake of many foods (like red meat once a month), and approach things like sugar and salt with informed trepidation. Think about it: sugar ain't what it used to be, nor is salt. Salt once had myriad minerals intact, nearly all of which were beneficial to health. Not today! Same with sugar, same with corporately-grown vegetables. Sugar is refined out of benefit then used in nearly everything packaged or cooked. And, the soil is so overworked there???s nothing good left in it.
    So, here's the case for naturally-raised and organic food, animal or plant, as expensive as they are: Heart attacks and cancer cost more than organic food. Do any of you out there - including you research doctors - really know how trace pesticides and engineered DNA play against trace medications in our water, air pollution and the lack of daily nutrition? Of course not. But, doesn't approaching this problem this way simply make sense? If it walks and quacks???
    The facts are we all have certain genetic tendencies, and we are not breathing, eating and medicating the way we once did (and for millions of years before this). The interplay is deadly.
    Be very picky about what you eat. Read every label. Call the numbers on the packaging. It's your body, it's your life. Trust me and the thousands of people and families who???ve been through cancer. You're not doing yourself ??? or society ??? a favor by having that "occasional" Big Mac

  • Posted By: Nins @ 07/07/2008 12:02:48 AM

    Did you know that if McCain is elected you will have to pay income tax on the value of the medical insurance that your employer gives you? Worse still, he is offering a tax break for people who pay their own insurance, BUT only $2,500 for individuals and $5,000 for families.

    Let's say you have a family of four. Your insurance policy costs would be at least $1,500-2,500 per month under a self-pay plan, which cost more than employer group plans. So, you pay $18,000 -$30,000 per year for insurance, and you get to deduct only $5,000 of that. If you paid $25,000 for you insurance, you would be out of pocket $20,000 per year. This is FAR WORSE than the current system, where if you are self employed you can deduct 100% of you medical insurance costs.

    So, if you're not self employed, you would stick with your Employer's plan. Employer plans for a family of four have a value of $900-$1,500 per month totaling 10,800-$18,000 per year. Surprise! On April 15th, you owe tax on all of that as INCOME to you. Say your bracket is 25%, and the value of your Employer medical plan is $14,000. You will OWE THE IRS an additional $3,500, and that's ON TOP of whatever monthly premium you already pay to your employer for your insurance.

    Many analysts say that McCain's new rules would encourage employers to stop offering health benefits. If that happened, then far fewer Americans would be insured than are insured today, because what family of four can afford $18,000-$30,000 out of pocket per year for self-pay health insurance?

    Furthermore, McCain's plan does not require insurance companies to cover pre-existing conditions of people who self-pay their insurance. People under employer group plans have all of their pre-existing conditions covered. This is a hugely unfair aspect of the current system. Insurance companies can afford to cover the pre-existing conditions of the much larger pool of people with group insurance, but they refuse to pay the pre-existing conditions on the smaller pool of self-pay customers. They have been allowed to price gouge the self-pay customers, which is a form of market manipulation that should be illegal.

    So let's say one of your kids had diabetes and you have high blood pressure, then your employer stops offering insurance. You now have to buy your own, but you and your child are INELIGIBLE due to pre-existing conditions. Oh, yeah, they will let you buy the insurance, but you can't use it for any pre-existing condition until you have paid on time every month for two years. And you know what happens at one year and 11 months? You get a letter saying your policy has been cancelled. I have many patients this has happened to.

    McCain's plan SUCKS.

    It does nothing to help middle class working Americans afford or obtain medical insurance. In fact, it makes the current system WORSE.

  • Posted By: Tan Boon Tee @ 06/27/2008 2:43:01 AM

    In 1993, I suffered from nose cancer. Fortunately it was diagnosed early enough before it spread to the brain and other parts of the body. After going through a week of chemotherapy and seven weeks of radiotherapy, I recovered.

    The cause of cancer has always been attributed to a person???s food intake, tobacco consumption, life style, physical constitution and genetic mutation. The various combinations of these factors generate different forms of cancer.
    It was believed that my nose cancer was partly due to the excessive amount of salted fish I had in my younger years, and Chinese are said to be more prone to have this kind of cancer compared with other races.

    With the advancement of medicine and biotechnology, chances of surviving this life-threatening malignancy are growing. I pray that it will be curable in the not so distant future.

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Your Lifestyle, Your Genes, And Cancer

New research explores the complex interactions that cause our most dreaded disease. A look into some of the steps you can take to reduce your risk.