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    The Biology of Bipolar Disorder

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    Anatomy of a Failure

    Mary Carmichael 11/7/2007 12:00:00 AM

    In September the AIDS community took a devastating blow when Merck halted an international human trial of the world's most promising potential vaccine against HIV. At the time, doctors revealed only that the vaccine—which uses an "adenovirus," or the common cold virus, to deliver HIV genes into the body—had not worked.

  • When The Body Attacks Itself

    Mary Carmichael 1/21/2007 12:00:00 AM

    The immune system is what keeps most people's bodies healthy and free of disease, but for as many as 23 million Americans, it is a cause of disease, too. In autoimmune disorders, the system goes haywire, mistaking the body's own tissues for foreign invaders and destroying them. Drugs for these conditions, which include type 1 diabetes, multiple sclerosis and lupus, have been elusive. But on Sunday, scientists are reporting in the journal Nature that they have found a set of 30 genes that go awry in autoimmune disorders—and that could be potential targets for cures. NEWSWEEK's Mary Carmichael spoke with two of the discoverers, Richard Young, a biologist at the Massachusetts Institute of Technology's Whitehead Institute, and Alexander Marson, an M.D./Ph.D. student in Young's lab. Excerpts:

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