We Fought Cancer…And Cancer Won.

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  • Posted By: rbarkley @ 09/08/2008 2:44:08 PM

    Another dimension of the war on cancer that we all just sort of side step is the cost associated with scientific advances and age-cohort driven cancer care. How are we to pay for all this great care. Payors (Medicare and commercial health plans) are working feverishly to reduce their cancer "medical cost" inflation by moving to more restrictive pharmacy benefit management and pre-treatment medical management approval processes. So, on the one hand, we are excited about funding breakthrough research, yet we appear disinterested/distracted when it comes to the question of who is going to pay for it all.

  • Posted By: olderwiser @ 09/07/2008 7:14:21 PM

    Cancer acts like a very intelligent parasite. How do we know that it hasn't been dormant in the body from birth or in a form of symbiosis where cancer and the body are in balance and no adverse symptoms appear? A good question to ask would be, "Does the cancer invade and weaken the body, or does the cancer exist happily in the body in some form and only cause rampant cell activity after the body weakens in some way?" It would be good to try to get into the mind of an intelligent cancer to solve the problem that we have with it. That is, if it is as it seems, a very intelligent parasite.

    • Posted By: hkmcs @ 09/07/2008 11:24:55 PM

      Your idea is completely ridiculous. Paraistes are defined as an organism that lives and feeds off *another* organism. Since cancer cells are derived from cells of the same organism, they're not parasites. So the kind of war and appeasement you discuss does not apply in this disease. It's also the main reason why it's so hard to treat cancer, because researchers/doctors must take care not to kill innocent bystanders, i.e. non-cancercous cells, in patients.

      • Posted By: olderwiser @ 09/08/2008 11:08:16 AM

        Thank you hkmcs for your opinion. The adverb, "completely", might be a little harsh. I can buy, "ridiculous", but it would be fair to leave a peephole into what might be an idea worth exploring. I am not referring to our own cells which finally multiply in the latter stages of cancer, but instead I refer to that condition prior to rampant cell production when the dormant instigator and the body are in symbiosis. Something is happening in there that we do not yet understand. It is furtive, elusive, and might even be intelligent. If it is not, then I do not wish to be shot at dawn for being wrong. I always thought that we were supposed to try to figure things out from what we observe over long periods of time. Cancer has killed all of my family which used to be alive and older than I am. Each type of cancer was different and seemed to be tailored to the type of victim. I'm talking grandparents, both parents, siblings and cousins. I am the only survivor, the last having died in 1983, my brother. So far, I have only had minor skin cancer. I base my question, not a closely held opinion, on observation of my people whom I watched get sick and die, one at a time, from different forms of cancer. I am not in the field of medicine, nor qualified in any way to say what cancer is. I simply said what seems to me to be a very possible scenario of what seems to happen with this mysterious disease that plagues so many people. Cheers to you, hkmcs, and I hope that you have a really nice day.

        • Posted By: olderwiser @ 09/08/2008 11:16:57 AM

          And, hkmcs, I might add that the term "war" is possibly an overstatement of what is being done about cancer these many years. This term seems to be popular to use in medical research, but is really not appropriate. Research is an inquisitive process and war is a process involving one or more populations trying to kill other populations and take their property, and even sometimes, just an exercise in raw revenge.

    • Posted By: olderwiser @ 09/07/2008 7:18:00 PM

      Maybe then, instead of trying to kill a form of existence like a very intelligent parasite, we could reason with it in some way to make a reasonable peace and co-exist in some reasonable way.

      • Posted By: olderwiser @ 09/07/2008 7:21:20 PM

        It might reply that it always has existed in peace with our bodies from birth and bemoans the fact that we weaken and become an unworthy host which kills it, too. I wonder if cancer is also trying to solve the problem of its unfortunate death in human beings of declining health. Surely it hasn't spent as much money as we have in this pursuit.

        • Posted By: olderwiser @ 09/07/2008 7:25:02 PM

          I plead with those who spend their lives honorably researching this question do not accuse me of appeasement with cancer. I just thought that it might be a good idea to at least look at the possibility of diplomacy in the matter. If it really is as intelligent as it seems, having baffled many great minds, then why not give it a try?

  • Posted By: mr.ak @ 09/07/2008 9:57:52 AM

    5 pages of how we can't cure cancer - one paragraph on prevention! That about sums up the war on cancer. At least the author hit the nail on the head about prevention not being profitable. Why don't we look at all the toxins we put into our food, already denatured and processed beyond recognition, toxins in our water (including some we add deliberately, like fluoride), toxins in the air, toxins everywhere.

    • Posted By: NormLB @ 09/08/2008 10:46:49 AM

      Well said! The fact that government, here in Canada too, give tax receipts to donors for this research is acknowledgement that many of their decisions will affect their constituents. I don't know if its ever been tried, but a class action suit against our Federal and State or City governments for the toxins we've been harmed with through their bad urban design decisions, power generation methods, industrial damage forgiveness (disproportionately low penalties for major contaminant emitters), would cost far more than $30 billion per year, or the 100's of millions in charitable donations. If over 500,000 will die from Cancer is the next 12 months, and the average funeral costs $10,000, plus insurance payments, legal costs, medical bills, the cost to the different levels of government would be devastating. For just one year's number of cancer deaths. Just one.

      I noticed some posters referring to God, or recovering via prayer. You're getting close to the cure. God gave us everything we needed to be. He gave us dominion. We gave dominion to governments, instead of sharing that with God. The recipe for that is within the last chapter of Ecclesiastes. If you read beyond the mythical language, you'll see that it really addresses the endocrine system and therefore the immune system. It basically says to let Divine motivation, thinking, intelligence permeate your every moments, and that gives you dominion over your own body. Divine dominion is very, very practical. My dad always wondered what the guy who invented sex was up to next. At first, it's funny, but when you realize that creation is why we live, and that our reproductive system is the peak of the endocrine system, the humorous aspect gets you wondering what the other 6 glands are there for.

  • Posted By: maric @ 09/08/2008 10:10:01 AM

    We're losing the war on cancer because the focus is on early detection and treatment, when it should be PREVENTION. However, most people don't want to hear that they're current lifestyle/diet will more than likely lead to cancer and most doctors are educated enough to know better about nutrition and long term affects of certain foods on the human body.

  • Posted By: NormLB @ 09/08/2008 10:05:58 AM

    Wonderfully refreshing piece of journalism! Facts, context, and food for thought! I really thought that good journalism had died. You've restored my faith!

    I guess my point is with respect to the failure to investigate Prevention more profoundly. Regardless of the Cancer Industry's money motive, other research and even moreso, just commonsense tells us that negative stress dillutes, if not disables, our immune systems. Norman Cousins proved that for himself with Laughter (is the best medicine). Meanwhile we merrily go along with the fears and concerns seeded by the media, poitical campaigns, wars on whatever, food infestations and reports of disasters, high crime rates, etc., taking them all in, and no mechanism to expell them, like food waste, or pimples.

    A good friend once told me that Cancer is "the will to die". We just accept that we're born and will eventually die. For now, that's probably the fact. But what if that was not the plan? How would we live differently? How would we build our towns and cities drifferently, school our children, pass on our knowledge, keep our eyes on the the next 100 years, and avoid fuel price stresses, food depletion... in other words, eliminate the larger, doom attitude stresses, and enjoy our potentials, far more?

    No money in that, because its something within each individual's grasp, But far better that, than wasting our short time on this 3rd rock from the Sun, in cancer therapy. IMHO.

  • Posted By: NormLB @ 09/08/2008 10:05:26 AM

    Wonderfully refreshing piece of journalism! Facts, context, and food for thought! I really thought that good journalism had died. You've restored my faith!

    I guess my point is with respect to the failure to investigate Prevention more profoundly. Regardless of the Cancer Industry's money motive, other research and even moreso, just commonsense tells us that negative stress dillutes, if not disables, our immune systems. Norman Cousins proved that for himself with Laughter (is the best medicine). Meanwhile we merrily go along with the fears and concerns seeded by the media, poitical campaigns, wars on whatever, food infestations and reports of disasters, high crime rates, etc., taking them all in, and no mechanism to expell them, like food waste, or pimples.

    A good friend once told me that Cancer is "the will to die". We just accept that we're born and will eventually die. For now, that's probably the fact. But what if that was not the plan? How would we live differently? How would we build our towns and cities drifferently, school our children, pass on our knowledge, keep our eyes on the the next 100 years, and avoid fuel price stresses, food depletion... in other words, eliminate the larger, doom attitude stresses, and enjoy our potentials, far more?

    No money in that, because its something within each individual's grasp, But far better that, than wasting our short time on this 3rd rock from the Sun, in cancer therapy. IMHO.

  • Posted By: woohoo @ 09/08/2008 7:23:03 AM

    they don't want to cure cancer. it provides too many jobs.

  • Posted By: bongya @ 09/08/2008 6:05:46 AM

    The key to these incurable diseases like cancer, diabetes and the like is to revive, rejuvenate, and recondition the mitochondria of the cells. When the mitochondria are energized they will restart the ATP pump which runs the Kreb cycle. Once these are up and about the cells will respond to "inputs" given them - medications, nutrients, etc. This is the reason why a treatment will work for one person but not on the next. The treatment did not fail. It was the other patient's body cells that failed.

    We have developed a supplement which energizes mitochondria through nanotechnology.

    Bong Yambao

  • Posted By: compubomb @ 09/08/2008 4:55:21 AM

    Greed is the primary cause of cancers. The day we started to invent new and interesting chemical compounds to do new and interesting things is the day cancers started to explode in the general population. Look at all of these 3rd world countries all over the world who have high death rates because of exposure to toxic compounds which inhibit or excite growths of all kinds in the human populations of those areas. If we start using caution before we throw things away and figure out ways of safe disposal then some of these cancers might be prevented.

  • Posted By: compubomb @ 09/08/2008 4:53:59 AM

    Greed is the primary cause of cancers. The day we started to invent new and interesting chemical compounds to do new and interesting things is the day cancers started to explode in the general population. Look at all of these 3rd world countries all over the world who have high death rates because of exposure to toxic compounds which inhibit or excite growths of all kinds in the human populations of those areas.

  • Posted By: Andrea M. @ 09/07/2008 5:26:37 PM

    Very good article. I have wondered many times how the cancer research industry, with all its funding, and over the course of several decades, has failed to produce anything close to a cure. Yes, cancer is complex and much remains to be learned about it, but it is 2008. Technology and science have made such tremendous strides, and yet the human body remains an enigma that we can't figure out? A woman is diagnosed with breast cancer, and the best the medical community can do is offer radiation, which in and of itself can be a carcinogen, toxic drugs, and disfiguring surgery? And after going through all that misery, the woman still cannot expect to live to see old age, but rather is considered successfully treated if she lives 6 or 7 more years? That is ridicuolus, and there must be more that can be done.

    • Posted By: hkmcs @ 09/07/2008 11:11:40 PM

      From what you wrote I can tell you're not in research. You know the main obstacle of research in human diseases? Because researchers can't test their hypothesis by directly doing experiments on human beings, unless that person is already diseased and willing to experiment, but a lot of times these volunteers are just too sick and information obtained from them wouldn't help patients at the initial stage of disease. The reason it takes so long and so much effort in research is because researchers have to look for ways around the aforementioned problem - like doing cell culture, using animal models, and even using primate models which should most closely estimate human physiology is hampered because of ethical issues. I'm not complaining that there shouldn't be any regulations, because they keep us safe and sane. Laypeople should understand the hardships in research before complaining. Researchers feel bad about patients dying, too, especially those who have relatives that are suffering from diseases. Be more sensitive and knowledgeable before you make such mindless statements.

      • Posted By: Andrea M. @ 09/08/2008 2:35:01 AM

        hkmcs,
        please don't take people's opinions so personally. I am merely agreeing with the author of the article, and sharing in her frustration that we have yet to find and implement a cure for a ravaging disease that affects the lives of so many.

  • Posted By: dilberth @ 09/08/2008 1:02:07 AM

    I believe that there is a definite link to cancer and longevity. The longer one lives the more chance that that person will get some form of cancer.

  • Posted By: grandma marianne @ 09/08/2008 12:47:38 AM

    I am just a regular grandma, but a healthy one. It seems obvious to me that modern lifestyles are to blame for those outbursts of genetic and/or unknown illnesses.
    Permissive education and psychiatric drugs are undermining and weakening us. Ready made food and chemical components as well as industrial diets leave our bodies vulnerable and unprepared to fight the attacks of other living cells that share our world with us. We need to turn back to the natural lifestyles and diets that were born out the primal needs of the human nature.

  • Posted By: Chuckweirdstone @ 09/08/2008 12:34:12 AM

    My brother and father both died within two years of each other. Both lung and brain cancer. It was quick for both of them. Not so much for me. As it turned out, they both hated me and cut me at every turn. God bless Cancer. Thin the heard.

  • Posted By: Gregory D. Pawelski @ 09/08/2008 12:25:03 AM

    To beat down cancer mortality, oncologists need to target all the many cancers that make up a cancer - the dozens of different pathways that cells use to proliferate and spread. That is the leading edge of research today, determining how this patient's tumor cells work and hitting those pathways with multiple drugs, simultaneously or sequentially, each chosen because it targets one of those growth, replication and angiogenesis pathways. The hope is to match tumor type to drug. We need to make the next leap, getting the right drug to the right patient. I agree!

    Cancer cells often have many mutations in many different pathways, so even if one route is shut down by a targeted treatment, the cancer cell may be able to use other routes. In other words, cancer cells have "backup systems" that allow them to survive. The result is that the drug does not shrink the tumor as expected. One approach to this problem is to target multiple pathways in a cancer cell.

    The key to understanding the genome is understanding how cells work. The "cell" is a system, an integrated, interacting network of genes, proteins and other cellular constituents that produce functions. You need to analyze the systems' response to drug treatments, not just one target or pathway. Another challenge is to identify for which patients the targeted treatment will be effective. Screening compounds for efficacy and biosafety.

    Tumors can become resistant to a targeted treatment, or the drug no longer works, even if it has previously been effective in shrinking a tumor. Drugs are combined with existing ones to target the tumor more effectively. Most cancers cannot be effectively treated with targeted drugs alone. You need to measure the net effect of all processes within the cancer, acting with and against each other in real time, and test living cells actually exposed to drugs and drug combinations of interest.

    Multi-targeted drugs can be well-predicted by measuring the effect of the drugs on the function (is the cell being killed regardless of the mechansim) of live cells, as opposed to a target (does the cell express a particular target the the drug is supposed to be attacking). While targeted screening tells you whether or not to give one drug, functional screening can find other compounds and combinations and can recommend them from the one analysis.

  • Posted By: Sandy63 @ 09/07/2008 11:45:26 PM

    Our cullture is death-phobic. Everyone dies. We are supposed to die. Yet we fight it tooth and nail.
    Our nursing homes are already filled with patients who are alive because they were rescued from a stroke or other severe health occurance. The intensive care units are filled with advanced elderly patients who are beyond hope for a recovery, and yet the assault on their bodies continues. the body is alive, but sometimes I wonder if the spirit hasn't already left the shell.
    If cancer and cardiovascular disease are defeated there would be catistrophic consequences for our culture. Elders out living their money would have a severe impact on the taxe rates of younger generations. Etc. Etc.
    Let's regain our spiritual and emotional focuses by striving to live our lives as fully as we can. Ponder our legacy, rather than living in fear . Of course dealth is a time for grieving, by both the dying one and dear ones left behind. Life on earth, by its nature is full of losses. Let's claim and feel our grief and celebrate that Granny finally made it out. In a culture dominated by religions which promise a better place beyond physical death, our irrational death phobia is contradictory.
    Let's change our focus to spending money to keep ourselves health. Changing our diets and cleaning our air will make our time here much more pleasant and will result in our living well; until it is time to leave. It's time for a spiritual awakening to the grace of nature's cycles.

    • Posted By: cmwillia @ 09/08/2008 12:02:12 AM

      Yes, we are meant to die and we do have an obsession with avoiding it. But, I'm one of the parents with a 4 year old with leukemia. I'm lucky--my kid is in the "good" group and "should" survive, I believe the quote in the article was "well into adulthood." The problem is, that phrase is a little scary for those of us in my boat. No one knows how long our kids will have because of the relatively short time pediatric cancer outlook has been so "good." And I am surrounded by parents who aren't so lucky and are watching their kids die. Yes, we need to accept that death is natural once you get up into your elder years and perhaps we shouldn't be bending over backwards to cure something that just naturally happens at that age. But please don't forget there are many many people with years and years left who need, desperatley need this research to continue.

  • Posted By: cwlidz @ 09/07/2008 10:47:15 PM

    One thing that is important to remember is that we all die and this is, strangely, a good thing. As my 9 year old grandson noted the other day, "If people didn't die there would be no room for people to be born". This is not to say that we should welcome cancer, but it should remind us to keep the whole thing in perspective. If I am not to die of cancer, is Alzheimer's better? Let us try to make the most of the time we are given.

  • Posted By: cwlidz @ 09/07/2008 10:46:56 PM

    One thing that is important to remember is that we all die and this is, strangely, a good thing. As my 9 year old grandson noted the other day, "If people didn't die there would be no room for people to be born". This is not to say that we should welcome cancer, but it should remind us to keep the whole thing in perspective. If I am not to die of cancer, is Alzheimer's better? Let us try to make the most of the time we are given.

  • Posted By: jme483 @ 09/07/2008 7:24:45 PM

    I am 3 years into an MD/PhD training program at a prestigious university. In those 3 short years, many of your observations have become abundantly evident, particularly in regards to research funding. The 30+ billion dollars a year that is spent by NIH through various agencies, including NCI, to fund researchers goes mostly to "safe" projects. In order for scientists to get funded (aka have a job), we are being forced to conduct research that is highly supported by what is already known and published. We therefore continue to study the same "sexy" and "popular" pathways and mechanisms in every disease process. However, as you point out, if these were truly as important as the researchers make them out to be we would have cured/developed therapies to better treat all of these diseases. The current funding system does NOT promote innovation of ideas and in my opinion actually rewards those who utilize stagnant ideas in some new disease or animal model. It is not until this mentality changes and we appreciate the fact that research is meant to be high-risk that we will begin to fund innovation. I believe that we will not truly benefit from the great effort (time, money, and resources) that is being put into research until this happens.

    • Posted By: just_askin @ 09/07/2008 10:02:27 PM

      What kind of innovative approaches would you favor? Your disparage the kind of basic science research (sexy/popular pathways) that give us a concrete way to think about the molecular underpinnings of cancer? Please enlighten us as to what will get us to the answer quicker.

      Your implication is that if these insights haven't yet paid off yet in the clinic (and some have), then the studies must have been a waste of time? What do you offer as an alternative, a kind of "faith-based" approach to cancer. Just trust a young investigator with a pile of money, without asking them to justify why the investment is likely to pay off?

      And yes, basic sciences research does pay off. The treatment of AIDS is the best example of how quickly progress can be made by hard-nosed conventional research.

      It's a dangerous thing to get into the sour grapes mode so early in your career. I've won and lost at the grant-getting game, as has everybody else. But there is one thing I do know, innovators find a way.

  • Posted By: The Medicine Man @ 09/07/2008 9:01:49 PM

    "In His masterpiece God installed the natural resistance to cancer, we must maintain it."
    Today the treatment is more deadly than the disease. Chemo is deadly poison and depleats our entire system. The answer is to revive our resistance, only the body can do any healing. Please visit www.curetocancer.com or www.the-medicine-man.org

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