HEALTH FOR LIFE M.D.

How to Help Anxious Minds

A Harvard psychiatrist answers questions about mental illness.

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  • Posted By: oneonone @ 05/04/2009 1:29:43 PM

    I am diagnosed as skizoaffective-bi-polar. It seems that the meds I have taken for 25 or more years have brought on shakiness in my hands. It has been very noticeable by physicians/people alike and they worry as I do. However, I need all the meds that I take. I have discussed this with them. Do you have any ideas for me to discuss with my psychiatrist that may help open any new avenues of thought in bringing this problem under control? I am afraid that I have burned out my brain.

  • Posted By: philroy59 @ 09/21/2008 1:34:55 AM

    Dr. Salzman asserts: "When psychiatric medications are taken as directed by a physician, there are no long-lasting harmful effects on the brain." Can Dr. Salzman cite any scientific evidence whatsoever to support this claim? Perhaps Dr. Salzman has somehow simply overlooked all the growing evidence that these medications often do produce harmful effects, including those listed below.

    I'm surprised that Newsweek would publish such a broad unsupported claim without basic fact-checking first, simply because it came from a Harvard "expert". Maybe it's time for Newsweek to write an in-depth article contrasting the latest findings and controversies about psychiatric medications against the long-running overhyped industry claims.

    - tardive dyskinesia and other movement disorders
    http://www.ncbi.nlm.nih.gov/pubmed/16171976
    http://www.ncbi.nlm.nih.gov/pubmed/18591121

    - endocrine effects that lead to obesity and diabetes
    http://www.ncbi.nlm.nih.gov/pubmed/16832314
    http://www.ncbi.nlm.nih.gov/pubmed/16187768

    - antipsychotic withdrawal induced psychosis
    http://www.ncbi.nlm.nih.gov/pubmed/16774655
    http://www.ncbi.nlm.nih.gov/pubmed/17650054

    - agranulocytosis, a potentially fatal blood disorder
    http://www.ncbi.nlm.nih.gov/pubmed/18681784

    - drug-induced structural brain changes
    http://www.ncbi.nlm.nih.gov/pubmed/15702141
    http://www.ncbi.nlm.nih.gov/pubmed/16612194

    - risk of suicide from antidepressants (blinded compared to placebo)
    http://www.ncbi.nlm.nih.gov/pubmed/12601224
    http://www.ncbi.nlm.nih.gov/pubmed/18690915

    - antidepressant discontinuation syndrome
    http://www.ncbi.nlm.nih.gov/pubmed/9219489
    http://www.ncbi.nlm.nih.gov/pubmed/9269249


    Using Imaging to Look at Changes in the Brain
    http://www.nytimes.com/2008/09/16/health/research/16conv.html

    Risks Found for Youths in New Antipsychotics
    http://www.nytimes.com/2008/09/15/health/research/15drug.html

    Judge to Unseal Documents on the Eli Lilly Drug Zyprexa
    http://www.nytimes.com/2008/09/06/business/06lilly.html

    Exposure to antipsychotics and risk of stroke
    http://www.bmj.com/cgi/content/full/337/aug28_2/a1227

    Several lawsuits target prescription drug Seroquel
    http://www.post-gazette.com/pg/08241/907556-53.stm

    Proof Is Scant on Psychiatric Drug Mix for Young
    http://www.nytimes.com/2006/11/23/health/23kids.html

    Psychiatric Group [APA] Faces Scrutiny Over Drug Industry Ties
    http://www.nytimes.com/2008/07/12/washington/12psych.html

    Stanford doctor's stock raises ethics concerns
    http://www.mercurynews.com/lifeandstyleheadlines/ci_9689122

    Grassley seeks FDA scrutiny of Paxil and suicide risk
    http://finance.senate.gov/press/Gpress/2008/prg061208.pdf


    Mental health journalism blog
    http://www.furiousseasons.com/

    Law Project for Psychiatric Rights
    http://psychrights.org/Research/Digest/Researchbytopic.htm

    MindFreedom International (UN-recognized NGO)
    http://www.mindfreedom.org/kb/psychiatric-drugs/

    "Mad in America" by Robert Whitaker
    http://madinamerica.com/Mad%20In%

  • Posted By: 49er @ 09/17/2008 6:13:58 PM

    Dr. Salzman's statement that psychotropic meds don't cause long term brain damage is simply not true. It is also outrageous that a news organization like Newsweek allowed a statement like this to go unchallenged.

    My story:

    I suffered many cognitive side effects and a hearing loss as the result of being on antidepressants which I am very slowly withdrawing from One of the cognitive side effects is very subtle but will occur in my writing. Even though I know which word to use, my fingers end up typing the wrong one. For example, in a post on a comments section, I meant to say ???enter??? and typed ???end???. It is like the drugs caused something in my brain to get crossed up as I never made these errors prior to being placed on meds.

    My story aside, there are citations that challenge this view

    1.http://www.ncbi.nlm.nih.gov/pubmed/17196056?dopt=AbstractPlus - A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term antidepressant treatment.

    2. http://www.annals-general-psychiatry.../1/7/abstract/ - Selective serotonin reuptake inhibitor use associates with apathy among depressed elderly: a case-control study

    Conclusion

    Even though depression was improved in elderly patients receiving antidepressants, apathy appeared to be greater in patients who were treated with SSRI than that found in patients who were not. Frontal lobe dysfunction due to alteration of serotonin is considered to be one of the possibilities.

    3. http://www.ncbi.nlm.nih.gov/pubmed/9640489
    Selective serotonin-reuptake inhibitor-induced movement disorders.

    4. not brain damage but still very serious ???
    http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum - Medication-induced mitochondrial damage and disease.

    ???All classes of psychotropic drugs have been documented to damage mitochondria,???

    AA

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