"You looked perfect. Don't listen to these haters, Deb!" Schumer wrote.
"I wasn't the only one 'talking' aka 'cheating' with other people during our 'relationship/marriage.'"
"It happens and it is what it is I cannot go back in time and change the past," he wrote on Sunday.
Dr. Phil McGraw was attempting to have an intervention on Friday with the actor.
"You know you don't want to see somebody in that kind of position to the point where they're actually putting out a cry for help on social media."
She starred in the long-running sitcom "Laverne & Shirley," and directed "Big," which was the first movie directed by a woman to make more than $100 million.
"You're absolutely right...I don't deserve Cate & trust me, karma has bitten me many times before, so I'm well equipped when she comes knocking again!"
"Leave me alone. & go on about your business," she wrote. "Go stress someone else out."