Comedian Garry Shandling Has Died at the Age of 66

Garry Shandling
The comedian and star of 'The Larry Sanders Show' died Thursday in a Los Angeles hospital. Mario Anzuoni/Reuters

Garry Shandling has died at the age of 66, TMZ first reported. The AP later confirmed the news. The comedian was reportedly in good health and speaking with people Thursday morning, but after a 911 call was transported to a Los Angeles hospital where he passed away.

Revered throughout the comedy community, Shandling was best known for creating and starring in The Larry Sanders Show, an ahead-of-its-time reality show parody that took viewers behind the scenes of a fictional late-night talk show hosted by Shandling's character, Larry Sanders. Running on HBO from 1992-1998, it paved the way for shows like Curb Your Enthusiasm. The series finale won Sanders an Emmy.

Prior to The Larry Sanders Show, Shandling was a well-respected comedy writer and stand-up comedian, often on The Tonight Show with Johnny Carson. He also created and starred in It's Garry Shandling's Show, which ran on Showtime from 1986-1990

On Sunday, Kathy Griffin tweeted a picture of herself with Shandling and Bob Odenkirk.

So @GarryShandling & I had to call Saul @mrBobOdenkirk

— Kathy Griffin (@kathygriffin) March 21, 2016

Earlier this year, Shandling appeared as a guest on Jerry Seinfeld's Comedians in Cars Getting Coffee. The title of the episode was, "It's Great That Garry Shandling Is Still Alive."

Comedians have been expressing sadness since news of Shandling's death broke.

Dammit. He was the best. So sad. RIP Garry Shandling

— marc maron (@marcmaron) March 24, 2016

R.I.P. Garry Shandling. I am so saddened to hear this. Brilliantly funny and such a great guy. He will be so missed.

— Albert Brooks (@AlbertBrooks) March 24, 2016

Saddened over Garry Shandling. He was a comedy idol of mine. He leaves behind the greatest single-camera comedy of all time. #LarrySanders

— Seth MacFarlane (@SethMacFarlane) March 24, 2016

Absolutely can't process the loss of Garry Shandling. Such a genius, such a wonderful man, such an inspiration. I was so honored to know him

— Paul Feig (@paulfeig) March 24, 2016

One of my favorite moments as a dad was hearing a 4 year old Malcolm say he "Watch Larry Sanders show." Thank you. RIP Garry Shandling.

— Ronald Funches (@RonFunches) March 24, 2016

The world has lost a comedy giant. An all time great. Hey Now Garry Shandling

— Howard Stern (@HowardStern) March 24, 2016

RIP Garry Shandling. #Irreplaceable

— Michael McKean (@MJMcKean) March 24, 2016

Garry Shandling was one of the most brilliant people I have ever known. A shocking huge loss.

— Billy Crystal (@BillyCrystal) March 24, 2016

The great Garry Shandling's work is such a touchstone for me that I was actually discussing him moments before I heard the sad news. RIP

— Stephen Merchant (@StephenMerchant) March 24, 2016

Garry Shandling was as kind and generous as he was funny and that is saying a lot.

— Jimmy Kimmel (@jimmykimmel) March 24, 2016

RIP the great Garry Shandling. Surely, one of the most influential comedians of a generation.

— Ricky Gervais (@rickygervais) March 24, 2016

RIP, Garry Shandling. You will be missed.

This post will be updated as new information becomes available.