The NEWSWEEK 50: House Speaker Nancy Pelosi

The smooth, steely Speaker of the House made it her mission to thwart George W. Bush. Now she must transform herself from leader of the opposition to leader of the loyalists. Sounds easy enough: Democratic president, Democratic Congress, no problem. But if the Dems hope to hang on to that majority, they must prove they can deliver on Barack Obama's ambitious promises. Pelosi's colleagues are an unruly, ever-bickering bunch, and it will take all of her formidable political skills (and plenty of cajoling, threatening and pleading) to make sure they put Obama's agenda ahead of their own egos. (Story continued below...)