NFL Week 5 Betting Odds, Predictions: Lines, Spread, Expert Picks for Every Game

Two of the teams expected to be among the NFL's best this season are coming into Week 5 trying to improve on a tough loss in the week prior. Of course, only one team can win on Sunday.

The Minnesota Vikings—coming off a loss to the L.A. Rams—will travel to Philadelphia to play the defending champion Eagles, who fell last week to the Tennessee Titans. It's a rematch of last year's NFC Championship, which the Eagles won in a landslide. Minnesota comes into the game with a 1-2-1 record while the Eagles are 2-2. Both could use a win.

"There will be a tremendous sense of urgency," Vikings QB Kirk Cousins said, according to ESPN. "We'll have an edge to us in our preparation, have an edge to us during our game. You know, they're the defending world champs. We're playing them in their place. They reloaded and added some talent. It's going to be a challenge, but that's really what this league is all about."

The Eagles loss in Week 4, meanwhile, was especially frustrating. They lost in overtime after jumping out to an early lead. QB Carson Wentz—in just his second start after coming back from an injury that ended his year last season—was hit quite a bit in the Titans matchup.

"We have to find a way to keep him upright," tight-end Zach Ertz told ESPN. "It's not always on the O-line. The receivers and tight ends, we have to do a better job of getting open; can't face third-and-10-plus situations where he's got to hold onto the ball to let the routes develop. It's a multitude of factors. It's not the O-line, they're great players, so we just have to get it fixed."

kirk cousins
Minnesota Vikings quarterback Kirk Cousins throws a pass on September 23, 2018, in Minneapolis, Minnesota. He'll play in Philadelphia on Sunday. Hannah Foslien/Getty Images

Listed below is the betting line—via Odds Shark (and Bovada if the line moved)—for the Eagles, Vikings game as well as every other game in Week 5 of the NFL season. Also included are predictions from David Steele at Sporting News, Kristopher Knox at Bleacher Report and John Breech at CBS Sports (note: these predictions are just for who will win the game, not against the spread.)

Thursday, October 4

-Indianapolis Colts at New England Patriots: Patriots -10; Sporting News, Bleacher Report and CBS all picked the Patriots.

Sunday, October 7

-Jacksonville Jaguars at Kansas City Chiefs: Chiefs -3; Sporting News and Bleacher Report picked the Chiefs, while CBS picked the Jaguars.

--Tennessee Titans at Buffalo Bills: Titans -3.5; Sporting News and Bleacher Report picked the Titans, while CBS picked the Bills.

-Atlanta Falcons at Pittsburgh Steelers: Steelers -3; Sporting News and Bleacher Report picked the Falcons, while CBS picked the Steelers.

-Denver Broncos at New York Jets: Jets -1; Sporting News, Bleacher Report and CBS all picked the Broncos.

-Green Bay Packers at Detroit Lions: Packers -1.5; Sporting News, Bleacher Report and CBS all picked the Packers.

-Baltimore Ravens at Cleveland Browns: Ravens -3; Sporting News, Bleacher Report and CBS all picked the Ravens.

-New York Giants at Carolina Panthers: Panthers -7; Sporting News, Bleacher Report and CBS all picked the Panthers.

-Miami Dolphins at Cincinnati Bengals: Bengals -6; Sporting News, Bleacher Report and CBS all picked the Bengals.

-Oakland Raiders at L.A. Chargers: Chargers -6; Sporting News, Bleacher Report and CBS all picked the Chargers.

-Arizona Cardinals at San Francisco 49ers: 49ers -4.5; Sporting News, Bleacher Report and CBS all picked the Cardinals.

-L.A. Rams at Seattle Seahawks: Rams -7.5; Sporting News, Bleacher Report and CBS all picked the Rams.

-Minnesota Vikings at Philadelphia Eagles: Eagles -3; Sporting News and CBS picked the Eagles, while Bleacher Report picked the Vikings.

-Dallas Cowboys at Houston Texans: Texans -3.5; Sporting News and Bleacher Report picked the Cowboys, while CBS picked the Texans.

Monday, October 8

-Washington at New Orleans Saints: Saints -6.5; Sporting News, Bleacher Report and CBS all picked the Saints.