The Catalans are on a two-game winless streak in all competitions and their coach is under severe pressure.
The Portuguese has overseen United's worst start to a league campaign in 26 years.
Premier League teams are already making summer plans.
The best of the rest go head-to-head on Saturday. But will it be a classic?
Jurgen Klopp's team takes on Jose Mourinho's at Anfield on Saturday, with United firm favorite.
Barcelona has made one of Jose Mourinho's forwards its top target.
Everything is going so smoothly for Mourinho's team, but could he be set to lose one of his strongest assets?
Manchester United has spent around £150 million this summer, strengthening Mourinho's team.
Chelsea takes on Arsenal in the 11th final at the north London venue on Saturday.
The Portuguese is a prolific winner in cup finals and has won the Champions League twice.
Ajax stand between United and a place in the Champions League next season.
Schweinsteiger was frozen out by José Mourinho.
The Chicago Fire midfielder harbors no resentment over his Old Trafford exit.
The Portuguese manager has been public with his criticism of select individuals.
Martial's second season at Old Trafford has not lived up to the first.
Benjamin Mendy has impressed for AS Monaco this season.
Everton travels to Old Trafford on Tuesday.
Schweinsteiger is moving to MLS side Chicago Fire.
Depay has disappointed at United.
The United manager has been impressed with midfielder Ander Herrera's playing.
Enrique announced he will leave Barcelona at the end of the season.
José Mourinho has already led United to two trophies this season.
Mourinho's new club is still in the hunt for trophies.
Pogba and Ibrahimovic linked up against Blackburn Rovers.
Ibrahimovic has scored 20 times this season.