Argentina vs Colombia is the first heavyweight clash of the tournament, while Chile vs Uruguay could be crucial.
The 46th edition of the tournament gets underway on Friday and promises to be one of the most even in years.
Brazil hosts the Copa America this year but has not won the tournament in 12 years and will be without Neymar.
Uruguay seems likely to prove a tough challenge for France, a squad considered one of the tournament favorites.
Last eight of the World Cup gets underway on Friday, with France vs Uruguay.
All eyes will be on Cristiano Ronaldo and Luis Suarez on Saturday.
Who should you support at the World Cup?
Real Madrid and Liverpool will pin their respective hopes on Ronaldo and Salah on Saturday.
Who’s going where this summer?
Ernesto Valverde’s team is marching toward the title in his first season in charge at the Nou Camp.
Ernesto Valverde’s team already has an 11-point lead on Real heading into the game.
The Brazilian only just left the club, joining Paris Saint Germain for £199 million in the summer.
Any of these signings would have been massive.
The Brazilian is reportedly in Portugal for a medical.
The German manager wants to beef up his squad after returning the club to the Champions League.
The Gunners appear set for a busy summer in the transfer market.
Who’s going where as the transfer window hits July?
The Guinea midfielder has excelled in the Bundesliga.
John Terry was the last academy product to establish himself in the Chelsea first-team…17 years ago.
Salah has signed in a £36.9 million deal.
Wenger looks set to enter his 22nd year as Arsenal manager.