Lydia Smith

By Lydia Smith

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The Spanish government has announced it will be launching a clinical trial into whether hydroxychloroquine and certain antiretrovirals can prevent frontline health workers from contracting COVID-19.

The research, dubbed the Clinical Trial for the Prevention of Coronavirus Infection in Health Workers (EPICOS) will study 4,000 health workers, from wardens to doctors, at 62 hospitals in 13 regions in Spain.

The EPICOS investigation will evaluate to what extent existing medicines may offer protection against coronavirus.

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One group of participants will be given the anti-malaria drug hydroxychloroquine, while another will take a combination of the antiretroviral medications emtricitabine and tenofovir, a medication currently used to treat and prevent HIV. A third group will be given a placebo.

The randomized double-blind clinical trial, which will be overseen by the Spanish Medicines Agency, will release its first results in four weeks' time.

The research is part of the World Health Organization's Solidarity trial, which was launched at the end of March as part of a global search for drugs to treat COVID-19. People aged 18 to 65 will be eligible to take part in the trial.

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"This is the largest clinical trial of this nature in Europe and one of the largest in the world in which, in addition to medical and nursing personnel, caretakers, radiology and laboratory technician pharmacists, that is, a broad representation of all the professions that are acting against the virus in the hospital environment," said Spain's Health Minister Salvador Illa.

The aim is to assess the risk of developing coronavirus in high-risk healthcare personnel.

Spain has Europe's highest number of confirmed cases with more than 157,000. As of Friday, the country has reported 15,800 deaths. The country has approved a 15-day extension to the national state of emergency,

Spain's Prime Minister Pedro Sánchez announced the country is close to passing the worst of its COVID-19 outbreak. "The fire starts to come under control... This war against the virus will be a total victory," he told MPs in Madrid.

The drug hydroxychloroquine is one of several being explored in clinical trials for the potential to reduce the severity of coronavirus symptoms or provide protection against infection.

Although many have touted the medication, including President Donald Trump, its effectiveness against the disease in the wider population is not yet known.

Experts in virology and infectious disease have warned that hydroxychloroquine can cause severe and life-threatening side effects. The drug, which is used to treat some autoimmune conditions such as lupus, should not be used to treat conditions for which it has not been tested, they say.

There have been various reports on how effective it is, but there is not yet any concrete evidence from large peer-reviewed studies that the drug works against coronavirus.

Newsweek has contacted Spain's Ministry of Health for a comment on the EPICOS research.

The graphic below, provided by Statista, illustrates the spread of COVID-19 across the globe as of April 9.

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