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Innovators in Japan Are Developing New Technologies to Counter Coronavirus

As the global coronavirus pandemic continues, the world is searching for new measures that will minimize the risk of infection while allowing essential institutions such as hospitals, government, and schools to continue to function. In any public health plan for public spaces, issues that must be addressed that include countermeasures against both viruses in the air and on surfaces that are touched by many people. Traditional disinfection measures have involved using chlorine-based cleansers or alcohol that are either sprayed or applied by hand. This approach, however, is not only labor intensive and of limited effectiveness, it also exposes cleaning staff to a greater risk of infection. Solutions are needed as we face this "new normal," and several innovators have stepped forward with some new ideas.

Crunching Numbers to Beat the Virus

The first step in any kind of research is creating models, and computers have been an invaluable tool in this process. Accurately simulating the motion of thousands of droplets through the air, however, has been beyond the capabilities of most available computers. To answer the need for more computation power, Japan's Institute of Physical and Chemical Research, or RIKEN, working in collaboration with Fujitsu, has developed the supercomputer Fugaku, currently the most powerful in the world. It went into operation in 2020—just in time to be put to use in combatting the fast-growing COVID-19 crisis.

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The supercomputer Fugaku, developed jointly by RIKEN and Fujitsu, is being put to work modeling how the coronavirus can spread.

Some of the first questions that Fugaku was tasked with answering involved the spread of the coronavirus through the air. By itself, the virus does not appear to be airborne; rather it travels inside droplets of fluid on the air, such as those released when an infected person coughs or sneezes. Fugaku was capable of running detailed simulations of how fluid particles can move through the air, allowing researchers to assess the risk levels not only from coughing, but also when speaking or singing. The simulations also provided convincing evidence that masks have a significant effect on reducing exposure, especially when worn by people who are infected. These findings were a tremendous help to public health authorities in providing safety guidelines that were clear, effective, and backed by evidence.

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Simulations produced by Fugaku have demonstrated how the virus can spread, and how effective masks can be, greatly helping health authorities. Provided by: RIKEN, Toyohashi Univ. Tech. In collaboration with: Kyoto Inst. Tech., Osaka Univ.

A further application of Fugaku has been in simulating the interaction between the proteins on the coronavirus and a wide range of medications. In just 10 days, Fugaku was able to test over 2,000 drugs, identifying dozens that showed promise as potential therapeutic treatments. No other computer or testing system developed so far has been able to produce so many results so quickly, and this has the potential of not only producing effective treatments for those infected with COVID-19, but a wide range of other diseases, as well.

Using Precision-Filtered Ultraviolet Light to Kill COVID-19 on Surfaces

A common expression in English is "Sunlight is the best disinfectant." This has turned out to be much more than just a figure of speech. Ultraviolet light, the same wavelength of sunlight that can cause tanning or sunburn, has long been used to sterilize medical equipment and other tools without the need for chemical treatments—which can potentially be harmful or produce chemical-resistant pathogens. UV light works because its high energy can break apart the chemical bonds of molecules inside microorganisms, preventing them from functioning or reproducing. These high energy levels, however, can also damage the cells in our bodies. To prevent UV leakage and to shield our eyes and skin, traditional UV disinfection must occur in sealed containers—making it impractical for large areas and for use in occupied rooms.

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Ushio’s Care222® i Series lamp can safely be used to suppress coronavirus in occupied rooms. © Ushio Inc.

Recognizing the urgent need for safe and effective sterilization technologies that can be used in occupied spaces, Ushio Inc. of Japan developed their Care222® lamp module. The technology uses a combination of an excimer-laser lamp that emits ultraviolet light concentrated around the 222-nanometer wavelength, and a unique filter that blocks potentially harmful photons of more than 230 nanometers from being emitted.

Ushio's Care222® i Series is capable of disinfecting spaces up to 2.5 meters away by 99 percent in only 6.3 minutes. This allows it to be installed on ceilings, where it can be used to continually disinfect public spaces in which many people make physical contact with surfaces, such as entrances, hallways, meeting rooms or restrooms, as well as frequently touched places such as handrails and doorknobs. With this technology, businesses and public facilities can continually contribute to protecting their employees and visitors.

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Care222® is capable of killing 99 percent of viruses from 2.5 meters away in just 6.3 minutes, making it ideal for continual sterilization of public spaces used by many people. © Ushio Inc

Adapting Ozone to Fight COVID-19 in the Air

Oxygen is perhaps the most vital element for human life, but it can also be a powerful weapon against coronavirus. The oxygen we breathe is actually molecular oxygen, which is made up of two oxygen atoms tightly bonded together. When on their own, lone oxygen atoms will react with, or oxidize, nearly anything, making them extremely effective for killing bacteria. Ozone is a special but easy-to-produce form of oxygen made up of three atoms bonded together. Because the molecule is unstable, it quickly breaks apart into a two-oxygen molecule and a microorganism-killing single oxygen atom. Ozone released into the air reverts back to ordinary molecular oxygen within a short time, leaving no harmful residues behind, making it a much more environmentally friendly disinfectant than bleach or other chlorine-based cleansers. Additionally, microorganisms cannot build up resistance to oxygen as they can to antibiotics. Based on this knowledge, Professor Takayuki Murata of Fujita Medical University in Japan's Aichi Prefecture, not far from Nagoya, began investigating whether ozone could be safely used as a preventive measure against coronavirus.

Ozone had been tested as a disinfectant in the past, and had been shown to be effective against viruses like the one that causes COVID-19. Unfortunately, ozone can be harmful if inhaled in high enough concentration, and previous testing had only been done at levels that would be dangerous for people. These tests had shown that ozone was effective for quickly disinfecting closed-off spaces, but it was impractical for disinfecting spaces used by many people throughout the day, or which could not easily be sealed off.

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The effectiveness of disinfecting with low-concentration ozone is tested against control groups with no ozone. © FUJITA HEALTH UNIVERSITY

Murata's team looked into whether ozone could be effective against coronavirus at concentrations low enough to be safe for people. The maximum limit for ozone was set at 0.1 part per million (ppm), so they began their investigations with concentrations of just 0.1 ppm. What they found was that maintaining a continuous low concentration could kill about 95 percent of infectious viruses within 10 hours. Furthermore, at concentrations of just 0.05 ppm, a level that is completely safe for people, the same reduction in virus levels could be achieved in 20 hours. This meant that very low concentrations of ozone could be used to disinfect high-traffic areas continuously. Murata's findings have already led several hospitals to install ozone generators in their waiting areas and patient rooms, and they are starting to be adopted for use in taxis and public transportation.

Creating a Better New Normal

Now that a vaccine has been developed, hope is growing that the end of the pandemic is in sight. But there is still a way to go, and millions of vulnerable people who need to be protected. Even after COVID-19 has passed, innovations like these will help to keep our workplaces and public spaces safer from new and existing pathogens, so that the next potential pandemic may be easier to control and prevent.

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