The two Americans meet in the first round of the Australian Open six months on after Gauff knocked Williams out of Wimbledon.
The first Grand Slam of the season begins in Melbourne on Monday, with some of the tournament favorites all in action.
A spot in Super Bowl LIV is at stake on Sunday as the 49ers and the Packers meet in the playoffs for the first time since 2014.
The Chiefs aim to return to play for the Lombardi Trophy for the first time in 51 years.
Mayweather retired for a third and final time after defeating McGregor in August 2017 but his latest Instagram post suggests a comeback may be on the cards.
The 108th edition of the Australian Open gets underway in Melbourne on Monday, with the women's and men's final scheduled for the first weekend of February.
Since Fox will carry the Super Bowl from Miami in two weeks, Sunday could be Romo's last game in the booth for CBS.
San Francisco is a seven-point favorite as the two teams meet in the NFC Championship Game for the first time since the 1997 season.
The Irishman is a heavy favorite to come out on top in Las Vegas in his first professional fight since October 2018.
The Chiefs enter the AFC Championship Game as 7.5-point favorite but must be wary of the Titans' excellent road record in the playoffs this season.
The Kentucky Derby, horse racing's premier event, has a long and storied history.
Fifty photos that capture a dizzying, exciting—and sometimes strange—year in sport.
From "Raging Bull" and "Rocky" to "Million Dollar Baby", "Ali" and the newly-released "Creed II", join us as we sort the featherweights from the heavyweight champions.
The Tigers clinched a first national title in 12 years on Monday, as they defeated Clemson 42-25 in New Orleans.
The Louisiana State University football team attended the White House in celebration of their national title.
One of only two kickers ever inducted in the Hall of Fame, the "Great Dane" reveals what is like to be a kicker in the NFL and whether the Chiefs can win the Super Bowl
Tweets from a now-deleted Twitter account spread through fans, players and baseball media alike with shocking new allegations.
On Thursday, the San Francisco Giants made history and hired Alyssa Nakken as one of the team's assistant coaches, making her the first full-time female coach in MLB history.
Novak Djokovic and Serena Williams are the bookmakers' favorite to add an eighth Australian Open title to their collections this year.
Defensive coordinator Dave Aranda was announced as the new head coach of Baylor on Thursday night, creating yet another big void for LSU as the offseason begins.
The tweet shows a video of Carlos Correa tossing his bat in the air, in celebration, with words that read, "Just feels like there's a buzz in the air."
Without Roger Clemens and the Black Sox and Mark McGwire and Gaylord Perry, baseball is boring.