The problem has been building since the 1980s, according to researchers.
The Appalachian Region Prescription Opioid strike force filed federal charges against 13 people, including 11 doctors, in connection with the opioid crisis in the Appalachian region.
The real Appalachia—a region of engaging diversity and culture—remains ripe for discovery.
The author has joined the investment firm Revolution's Rise of the Rest initiative to fund entrepreneurs in neglected areas.
The world-record-holding ultramarathoner just finished running the Appalachian Trail in 46 days, averaging about 50 miles a day: "My feet are so sore right now."