The spacewalk is expected to last more than five hours, according to NASA.
This is the first time in over fifty years of space exploration that two women will space-walk at the same time.
The building was constructed as a facility to quarantine astronauts and the material they brought back from the moon during the Apollo program.
Pitt plays an astronaut in the upcoming space opera Ad Astra, which will be in cinemas across the United States on September 20.
The main aim of the spacewalk is to install a special piece of equipment which will enable the space station to accommodate new spacecraft designed by private companies.
NASA is hosting a variety of events which will be televised on the space agency's own TV channel to commemorate the 50th anniversary of the first moon landing.
The race to the moon galvanized a nation in turmoil. Can we do it again? Space travelers Charlie Duke, Michael Collins, Al Worden and Russell Schweickart talk about their historic missions.
Before sending humans to Mars or the moon, scientists need to understand what long-term space living does to the human body. Now results are coming in from the Kelly brothers in the TWINS Study.
Armstrong made his "historic leap for mankind" when he walked on the moon on July 20, 1969. But three years earlier, he'd performed another, salvaging a mission that could have derailed the space program.
They're the first astronauts to launch to the station since the October mission that ended in an emergency crash landing.
Russian space agency head Dmitry Rogozin said he is not ruling out "deliberate interference in space."
It's the first space flight for some of the astronauts, while others have years of experience.
If it's anything like the lake beneath the ice of Antarctica, it might just harbor life.
Astronauts likely would not have survived the nearly three-year journey on existing spacecraft, a former astronaut said.
Almost two-thirds of respondents thought climate and asteroid monitoring should be top priorities for the agency.
Astronauts Drew Feustel and Rocky Arnold will spend more than six hours outside of the ISS Wednesday.
Astronauts on the International Space Station do not even have sinks because of the way water behaves in microgravity.
The colony sites are based on where astronauts would have the best luck growing crops.