Barcelona looks to remain top of the table when it travels to Madrid, while Atletico will be looking for its first league win against the Catalans in nine years.
The Serie A giants will top Group D with a win on Tuesday, while Atletico will qualify if it wins in Turin.
Two of the Champions League dark horses meet on Tuesday afternoon when Atletico Madrid hosts Juventus.
Defending champions Barcelona get the ball rolling on Friday when they take on Athletic Bilbao.
The MLS All-Stars will be looking for a first win since 2015 when they take on the Spanish giants Wednesday.
The two Spanish giants take their rivalry to the U.S. as they go head-to-head at MetLife Stadium on Friday.
The Frenchman will end his 22-year reign at Huddersfield, not a European cup final.
A place in the Europa League final is the prize.
Ernesto Valverde's team is marching toward the title in his first season in charge at the Nou Camp.
Manchester United had a big transfer planned for next summer, but it could be in jeopardy.
The transfer window may have only just closed but Jose Mourinho is already scouting potential signings.
The Portuguese coach already has an eye on the business his team will do next summer.
Any of these signings would have been massive.
The Manchester United man talks about Antoine Griezmann's future.
United is keen on Monaco striker Kylian Mbappe.
Ronaldo almost single-handedly saw off Atletico Madrid.
Leicester was the only English team to reach the quarterfinals.
Ronaldo became the first player to achieve 100 Champions League goals.
Thomas Tuchel says his team needed more time following the bus attack.
Football was quick to wish Dortmund well.
Ranieri won the Premier League with Leicester last season.
A Spanish publication said Real's president may be prepared to offload a striker after disappointing performances against local rival Atletico.
The transfer window reopens on July 1.
Antoine Griezmann has been linked all season with United.