Iran's Ayatollah Ali Khamenei said Mecca "belongs to all Muslims," and their security during Hajj was a God-given right that Saudi Arabia fails to uphold.
"The one who must leave is the U.S., not the Islamic Republic. We are from this region: the Persian Gulf is our home; West Asia is our home," Khamenei said.
The Ayatollah said Muslims must resist arrogant western nations.
Iranian officials have called for users to leave the encrypted messenger and move to a homemade alternative, complete with "death to America" and "Let's pray" stickers.
Iran is sending officials to Lebanon, Iraq and Syria as tensions mount with Israel, Saudi Arabia and the U.S.
Iranian supreme leader Ayatollah Ali Khamenei says it's the Islamic Republic's duty to protect citizens from social media companies stealing their data.
The U.S. and Iran are both fighting ISIS, but accuse one another of destabilizing the Middle East.
Iran's supreme leader Ayatollah Ali Khamenei said, "what the Saudis do...is certainly a betrayal of the Islamic Ummah and the Muslim World."
In 1953, the CIA backed a coup against democratically elected Iranian Prime Minister Mohammad Mossadegh, restoring absolute power to the Shah.
Iranian officials accused the U.S. of once again meddling in their internal affairs and offered to help Trump address his own hunger problem.
In Kermanshah, where the largest demonstrations took place, protesters shouted slogans against the Iranian leader Ayatollah Khamenei.
Ayatollah Ali Khamenei said President Donald Trump has insulted the Iranian people ahead of an important national holiday.
"I have a Twitter account and I think it is a suitable tool for public diplomacy, connecting to people around the globe and voicing our ideas."
The remarks by Ayatollah Ali Khamenei followed a wave of arrests of journalists and intellectuals.
He had traveled from his home in Dubai to visit relatives.
Rouhani needs sanctions lifted quickly; Khamenei just ordered him to move slowly.