Sayoc was charged with five felony counts, including interstate transportation and illegal mailing of explosives, threatening a former president, making threatening interstate communications and assaulting federal officers.
"Nobody in my administration got indicted. So, how is it that they've cleaned things up?" Obama added.
"I'm hoping that maybe this is a turning point," former CIA Director John Brennan said.
"Here's your chance to vote for people who actually know what the internet is," Obama said. "You wouldn't let your grandparents pick your playlist. Why would you let them pick your representative who's going to determine your future?"
Wheeler took over from Scott Pruitt after Pruitt resigned following a string of scandals and misconduct allegations.
Advocates argued that Columbus celebrations whitewashed the explorer's true legacy.
"I am so grateful to him for his service; he's going to go down as one of the greatest presidents. And yet, this [election] is on Texas," said O'Rourke.
"I will never forget [the] incredible experience and the stories I heard," Melania Trump said.
Rachel Crooks will face off against Republican incumbent Bill Reineke in November.
Gosar said that this is just a "minor drop in the bucket" compared to the attacks President Donald Trump has faced.
"It wasn't enough to [fire me], they had to so cruelly insult the people who loved that family and that show," Barr said.
"There's a huge difference between an isolated slip of the tongue and ceaseless, shameless, and witless prevarication," George Conway said.
"During his recent hour-long speech he talked a lot... About himself... 102 times in one hour," Hannity said.
The president said his rivals had "tried every trick in the playbook."
The Vice President's comments came after Obama sternly rebuked Trump during two speeches this week.
"It's always tempting for politicians, for their own gain and for people in power, to try to see if they can divide people," Obama said.
Previous Presidents have conducted lie detector tests on administration staff too.
"We are Americans, we're supposed to stand up to bullies. Not follow them," Obama said.
"People don't say it, but Obama had the same law that I did, and they separated parents from their children," Trump said, incorrectly.
"[Trump] speaks my language," Duterte, 73, said. "Obama...you are now a civilian and I am sorry for uttering those words."
The powerful speeches appeared to take digs at the president.
Deepfake videos spiked in popularity last year as the technology needed to create such content became more user-friendly.