"As the legacy of #BeBest comes to a close at the @WhiteHouse, we must continue to give a voice to our Nation's children and the issues that impact their lives," Melania tweeted on Friday.
The first lady made her remarks while delivering a speech at the PTA Legislative Conference in Alexandria, Virginia.
"Why would a woman of no achievements have been selected?" wrote Florida resident Carol Bodeen.
Palm Beach Atlantic University praised first lady as an "exquisite human being" for heading White House initiative.
After Trump called out the teenage climate change activist, people called on the first lady to condemn his remarks.
"I am in this fight with you, and I am fighting for you," said the first lady, despite being booed by the Baltimore crowd.
Parents have complained about Trump's visits to schools and events with children, but the first lady has rarely faced an actual protest.
The first lady will meet with children and "encourage them to spend more time outdoors & learn about our amazing National Parks," her spokeswoman tweeted.
"She seems like a very happy young girl looking forward to a bright and wonderful future," President Trump tweeted about Thunberg.
"I am profoundly disappointed by the decision to accept this invitation," a United Nations worker and parent wrote in a letter to the U.N. undersecretary-general.
"As students across the country head back to classes, I want to wish everyone a successful school year!" the first lady tweeted.
"Your work is saving lives and helping children," Melania Trump said of Twitter, Facebook, Google and other organizations.
The one-year Be Best celebration is an opportunity to "set plans for expanding the initiative in the coming year," the first lady stated.
Unlike the first lady, the former president did not call on children to fight back against bullies.
His new comrades recognized a kindred spirit through his sleepy protest.
The remark by the first lady, who has faced criticism for her "Be Best" initiative to fight cyberbullying, drew cheers from students at a Christian university in Virginia.
The White House's Christmas theme this year is "American Treasures."
Lemon asked, "Why is this relevant right now?"
"I remain committed to tackling this topic because it will provide a better world for our children," the first lady said.
"Yes I was naked, but I've been naked before," Melania Trump impersonator Melanie Marden says in her new Instagram video.
Melania Trump gave a speech on cyberbullying as her husband attacked his foes on Twitter.
Social media "can be used in many positive ways, but it can also be destructive and harmful when used incorrectly," Melania Trump said in her speech.
The president reportedly replaced Melania's modern-style furniture with pieces of "the gilded, triumphal style of Louis XIV."
Social media users also mocked the first lady and "Be Best" for what they deemed to be bad grammar.