The Baltimore Ravens took control of the AFC with a 20-17 over San Francisco, which saw the 49ers slip to fifth in the NFC.
The New Orleans Saints became the first team to clinch a playoff spot this season with a 26-18 win over the Atlanta Falcons on Thanksgiving.
Jason Garrett is under pressure from franchise owner Jerry Jones as the 6-5 Cowboys host the 8-3 Bills on Thursday.
The NFL's triple-header on Thanksgiving last year saw the fourth most wagers placed on a sporting event in the U.S. in 2018.
The NFL's Thanksgiving tradition continues this year, as the Lions host the Bears and the Cowboys welcome the Bills, while the Saints take on the Falcons.
Week 13 features three games on Thanksgiving Day, while the New England Patriots face the Texans in Houston on "Sunday Night Football."
The Patriots and the Chiefs look set to win their divisions, while the Chargers and Browns face a battle to reach the playoffs.
The Lions are looking for a first win in preseason when they host the Bills on Friday night, while Buffalo aims for a third straight victory.
The Steelers' wide receiver described rumors of a move to the Bills as "fake news."
A video of the incident showed blood stains covering the hallway where the altercation unfolded.
The Jaguars beat the Bills in Florida.
There's no Sunday Night Football, but still plenty to watch.
"Gronk" doesn't usually do this kind of thing.
The Bills are worth watching this season.
There's a lot of very poor football and a glut of very average teams. And that is making it tremendous fun to watch.
Trump tried to buy the Bills in 2014.
"Kathryn Smith has done an outstanding job in the seven years that she has worked with our staff," Rex Ryan said in a statement.
And it's not the first time that the Bills' uniform and color blindness have appeared in the same sentence.
A Buffalo Bills vs. Jacksonville Jaguars game in October will make history as the first to be shown online, not on TV.