Morgenthau served as Manhattan's district attorney for 35 years, dealing with roughly 100,000 cases a year.
"You have people on both sides of that," he said on Tuesday at a press gaggle. "They admitted their guilt."
Activists have called for cases handled by Linda Fairstein and Elizabeth Lederer to be reviewed following the release of Netflix series "When They See Us."
15-year-old Antron McCray was instructed by his father to confess to the rape and assault of Trisha Meili.
The 44-year-old first reached out to the filmmaker over Twitter in 2015 about making a show on the Central Park Five.
Played by Jharrel Jerome in the show, 16-year-old Korey Wise was one of the five black teenagers wrongly convicted of raping and assaulting Trisha Meili in 1989.
The petition, which was created after "When They See Us" premiered on Netflix, gathered more than 12,000 signatures in two days.
Matias Reyes confessed to raping and assaulting Trish Meili in 2002, leading to the exoneration of the wrongly imprisoned Central Park Five.
Fairstein, played in the show by Felicity Huffman, was reportedly personally involved in securing the false confessions of the five men.
From a false accusations to eventual freedom, five men started a loud, national conversation on race and flaws in the American justice system.
Jerome called the criminal justice reform advocate a "role model and an inspiration."
Before he was president, Donald Trump took out a full-page ad in some of New York City's most popular newspapers to condemn the Central Park Five.
"They were innocent. And the system failed them."
President Donald Trump has continued to suggest the five were guilty of raping and beating a woman, despite their convictions having been overturned.
Men say they were never afforded the "due process" the president expects for ex–White House aides accused of abuse.