Dallas looks to snap a two-game losing streak and consolidate its lead in the NFC East when it takes on the 6-6 Bears in Chicago.
Thanksgiving's football bonanza kicks off when the Lions host their NFC North rivals looking to snap a four-game losing streak.
The NFL's triple-header on Thanksgiving last year saw the fourth most wagers placed on a sporting event in the U.S. in 2018.
The NFL's Thanksgiving tradition continues this year, as the Lions host the Bears and the Cowboys welcome the Bills, while the Saints take on the Falcons.
Week 13 features three games on Thanksgiving Day, while the New England Patriots face the Texans in Houston on "Sunday Night Football."
Two struggling teams and two struggling offenses meet in Los Angeles as the Rams and the Bears look to keep their faint playoff hopes alive.
The 32-year-old quarterback will hold a private workout organized by the NFL in Atlanta on Saturday, to which all 32 NFL teams have been invited.
Week 11 begins on Thursday night with a crucial AFC North matchup as the Cleveland Browns host the Pittsburgh Steelers.
"It's just the outside viewers looking in," Bears quarterback Mitch Trubisky said of the outside noise from sports talk hosts needling on the team's subpar season.
The 49ers are off to their best start in almost three decades, while the Packers and the Saints look nailed-on to reach the playoffs.
The Oakland Raiders became the first team to win an NFL game at the Tottenham Hotspur Stadium on Sunday and three more games are scheduled in London over the next four weeks.
Chicago's struggling offense looks to get going against Washington, while the Redskins hope to avoid going 0-3.
Week 3 of the regular season kicks off on Thursday night when the Jacksonville Jaguars host the Tennessee Titans.
The 100th NFL season gets underway on Thursday night as the Bears host the Packers at Soldier Field.
The Bears travel to New Jersey looking for a first preseason win, while the Giants look to make it two in two.
The 100th season begins on Thursday, September 5, when the Chicago Bears host the Green Bay Packers.
The New England Patriots and the Kansas City Chiefs are the bookmakers' favorites, followed by the Los Angeles Rams and the New Orleans Saints.
Eighteen NFL franchises have already began training camp and the remaining 14 teams will do so by the end of the week.
The Bears moved to 9-6 after beating the Rams 15-6 on Sunday night.
The Packers inspired a memorable comeback on Sunday night, as Green Bay overturned a 20-0 deficit.
The Patriots have steamrollered the limited competition the AFC has to offer.
Many in Chicago are unhappy with the team's current head coach.
Adams was taken to the hospital after a helmet-to-helmet hit, raising the specter of concussion in the game once more.