"Corriere dello Sport" published the headline under pictures of Inter Milan striker Romelu Lukaku and Roma defender Chris Smalling.
The striker and defender suffered knee problems on Thursday evening.
Chris Smalling and Phil Jones were injured while on international duty.
Phil Jones suffered a toe injury in England training.
The Manchester United manager needs a replacement for the departing Eric Bailly.
Mourinho has suffered from injuries within his squad in recent weeks.
Chris Smalling and Luke Shaw were singled out by Mourinho.
Mourinho has criticized his defenders.
"For the team, you have to do anything."
Matteo Darmian's agent has hinted at a move from Old Trafford.
Mourinho may need to sell before he buys.
Jose Fonte pledged his allegiance to Southampton in the summer.
Mourinho will lose defender Eric Bailly to the Africa Cup of Nations in January.
Roy Hodgson's team kicks off its Euro 2016 campaign on Saturday.
The Dutchman didn't leave a completely negative legacy at Old Trafford.
Eric Bailly has agreed terms on a move to Old Trafford.
Could this finally be a Nemanja Vidic replacement?