The defending national champions could extend their winning record to 19 games when they host the 49ers this weekend.
Tua Tagovailoa, Jalen Hurts and Joe Burrow have emerged as the runaway favorites for the award after the first three games of the season.
Week 4 features three matchups between Top-25 ranked teams, including a major test for Georgia, which takes on Notre Dame.
Clemson could extend its winning streak to a school-record 18 games with a victory on the road against Syracuse.
No. 1-ranked Clemson travels to Syracuse, while No.2-ranked Alabama takes on South Carolina on the road.
The defending champions look to extend their winning streak to 17 games and are heavy favorites against the Aggies.
Defending champion Clemson hosts No. 12 Texas A&M, while No. 2 Alabama and No. 3 Georgia take on New Mexico State and Murray State.
The defending national champions kick off their campaign against Georgia Tech in front of their own fans on Thursday.
The college football season begins in earnest on Thursday, and Clemson and Alabama again look favorites to go head-to-head for the national title.
Clemson begins the defense of its national title on Thursday when it hosts Georgia Tech, while Alabama opens its campaign on Saturday against Duke.
Alabama's quarterback Tua Tagovailoa and Clemson's signal-caller Trevor Lawrence lead the race for the Heisman Trophy.
Clemson is the favorite to retain its national title this season, closely followed by Alabama and Georgia.
Week Zero of the 2019 season gets underway on Saturday, before the FBS heavyweights take the field on Thursday.
ESPN hosts criticized President Donald Trump for offering players from NCAA Football champion team Clemson University an array of fast food, labeling it a potentially racist move by the White House.
"I could care less about college football. But I'm personally inviting the Clemson Tigers team and coaches to Chicago to experience what an actual celebration dinner should be."
Clark's landing on Notre Dame fans didn't bring the team any good fortune.
Games are being moved or canceled as Hurricane Florence's landfall nears.
Will the Tigers pull off another upset?
This one is going to be talked about for a long time.
The Tide need help to make the postseason.
Nick Saban's team won't be in the SEC Championship Game.
Clemson dethroned defending national champion Alabama on a touchdown pass with 0:01 remaining.
Clemson and LSU finished first and second in the rankings, respectively.