The Patriots and the Chiefs look set to win their divisions, while the Chargers and Browns face a battle to reach the playoffs.
On Monday night Nick Bosa, defensive end for the San Francisco's 49ers imitated Browns quarterback Baker Mayfield's celebration in college. The celebration occurred after the Oklahoma Sooners led by Mayfield beat the Ohio State Buckeyes where Bosa played.
The 49ers look to extend its perfect start of the season to 4-0, while the Browns aim to take sole control of the AFC North.
The Cleveland Browns look to improve to 2-1 when they host the Los Angeles Rams, who are seeking a third consecutive win.
Both the Browns and the Jets will be desperate to avoid a second consecutive defeat when they meet at MetLife Stadium on Monday night.
Week 3 of the regular season kicks off on Thursday night when the Jacksonville Jaguars host the Tennessee Titans.
The Patriots travel to Miami in what could be a hopelessly lopsided game, while Cleveland must turn things around on Monday night on the road against the Jets.
An unnamed Cleveland Browns fan was captured on camera by 19 News' live broadcast as he fell off the top of a van on Sunday morning.
The 100th NFL season gets underway on Thursday as the Chicago Bears host the Green Bay Packers at Soldier Field.
The Indianapolis Colts are likely to be without Andrew Luck as they look to bounce back after losing to the Buffalo Bills last week.
Week 2 of the NFL preseason begins Thursday night with eight games nationally broadcast over the following four days.
Week 1 of the NFL season sees the New Orleans Saints hosting the Houston Texans and the Oakland Raiders welcoming the Denver Broncos.
Robert Stewart couldn't contain his excitement after the Browns confirmed OBJ's signing.
Hunt remains under investigation from the NFL, but could be available in time for training camp in April.
Number one overall pick completed 17 passes and helped the Browns overcome a 14-point deficit.
The Browns missed a PAT attempt to win the game on Sunday against New Orleans and lost in overtime.
Aaron Goldhammer was so sure the Browns wouldn't pick Mayfield than he vowed to eat horse p**p if they did.
The wide receiver left Miami after four seasons in March in exchange for two draft picks.
Bud Light has installed "Victory Fridges" around Cleveland that will unlock only if the Browns win a game.
Wide receiver was cut by the Dallas Cowboys on April 13.
The Browns were expected to pick either Sam Darnold or Josh Allen at number one.
Beckham has reportedly stated he will not play this season unless he agrees a lucrative contract extension.