Alabama quarterback Tua Tagovailoa was injured in the second quarter of Saturday's game against Mississippi, after recovering from a sprained ankle in October.
Saturday's matchup in Waco could serve as the dress rehearsal for the Big 12 Championship Game and could determine both programs' CFP chances.
After winning the remake of the "Game of the Century," the No.1-ranked Tigers look to strengthen their gap on the SEC West.
Minnesota's win over undefeated Penn State vaulted it from No.17 to No.8 in the CFP rankings and the Gophers look to keep their undefeated run going against No.23 Iowa on Saturday.
The No.2-ranked Buckeyes travel to New Jersey as a whopping 52-favorite as they look to improve their record to 10-0.
No.4 ranked Georgia travels to Alabama looking to consolidate its playoff hopes, while No.12 ranked Auburn looks to keep its season alive.
The reigning national champions have secured a fifth consecutive divisional title and can move within one game of finishing a second straight regular season undefeated.
The Crimson Tide is in danger of missing out on the College Football Playoff for the first time in history after falling to No.5 in the CFP rankings.
While appearing on Fox Sports "The Herd" former NFL quarterback and NFL insider, Trent Dilfer talked about Alabama quarterback Tua Tagovailoa and how he compares to his fellow college quarterbacks.
The top three teams ranked by the College Football Playoff Committee -- LSU, Ohio State and Clemson -- were also the top choices in the poll.
Clemson is back in the top four, while Alabama could miss the playoffs and the Big 12 has work to do.
Burrow's current odds are a big jump from last week and a massive jump from the start of the season.
LSU is expected to claim the No. 1 spot in the CFP rankings, while Alabama could fall out of the top four after losing to the Tigers.
Following the 46-41 over Alabama LSU tops both polls and is expected to claim to the No.1 spot in the new set of College Football Playoff ranking on Tuesday.
President Donald Trump received a welcome from fans at Bryant-Denny Stadium Saturday as the University of Alabama faced off against Louisiana State University.
The defending national champions were ranked at No.5 by the College Football Playoff committee and have no room for error.
Iowa travels to Wisconsin on Saturday in one of only three top-25 matchups in Week 11 of the college football season.
The two SEC rivals collide in the most anticipated match of the college football regular season on Saturday.
Two of the seven remaining undefeated teams in the FBS collide as the No.5-ranked Nittany Lions travel to Minnesota to take on No.13 Golden Gophers.
The Buckeyes look to improve to 9-0 after claiming top spot in the first College Football Playoff ranking of the season.
Following Ohio State's announcement stating that the team's defensive end and Heisman trophy hopeful would be ruled out of their upcoming game against Maryland, #FreeChaseYoung began to trend on Twitter.
Saturday's "Game of the Century" in Tuscaloosa will have huge implications for both the SEC title and the College Football Playoff race.
In the last 11 seasons, Alabama has lost just four times at home during the regular season and is unbeaten in Tuscaloosa since 2015.
Alabama is a six-point favorite ahead, but LSU is 6-0 against the spread since Ed Orgeron took over as full-time head coach.
It's a big weekend ahead with the 30th anniversary of the fall of the Berlin Wall and 'Sesame Street' turning 50.
"By the way, this Saturday, I'm gonna be at a certain game," Trump said. Before he spoke again, the crowd erupted into an "LSU, LSU, LSU" chant.
Being ranked No. 5 by the College Football Playoff Selection Committee hasn't dampened the Tigers' odds at several sportsbooks.
"It doesn't matter whether you're a Democrat or a Republican, (having) the president at the game is pretty cool," Burrow told The Advocate.
The College Football Playoff Committee will release its first rankings of the year on Tuesday, November 6.