LSU, Ohio State and Clemson are expected to retain the top three spots, while Utah could climb up to sixth.
It could be a political move for Saban, who needs his team to not only win against its in-state rival on Saturday, but needs some dominoes to fall so the Crimson Tide can make another playoff run.
The Sooners clinched a spot in this year's Big 12 Championship game by winning its last three games in a way that's so rare it hasn't been done since 2000.
The final week of regular season features a number of potentially crucial games, with Auburn taking on Alabama in the Iron Bowl and Ohio State traveling to Michigan.
Oklahoma climbed up two spots to No.8 in the latest CFP ranking after a spirited comeback against Baylor put in control of the conference.
The Tigers are 44-point favorite against the Razorbacks, the biggest point spread in SEC games in the last four decades.
Georgia has already clinched the SEC East title and a win against the Aggies would further consolidate its hopes of reaching the College Football Playoff.
The No.2-ranked Buckeyes host the No.9-ranked Nittany Lions in the de-facto title decider in the Big Ten East.
After losing its star quarterback to a season-ending injury, No.5-ranked Alabama has two games to force its way into the CFP top four.
LSU's Joe Burrow continues to dominate the conversation for the Heisman Trophy, though other names are emerging after the injury to Alabama quarterback Tua Tagovailoa.
The Crimson Tide remained at No.5 in the latest set of CFP rankings, with LSU, Ohio State, Clemson and Georgia occupying the first four spots.
There are two weekends of regular season remaining, plus the conference championship weekend before the final rankings are released, and anything can still happen.
The CFP selection committee will release its latest set of rankings on Tuesday evening at 7 p.m. ET during its traditional show on ESPN.
LSU, Ohio State, Clemson and Georgia should again make the top four of the CFP, while Oregon and UCLA are closing in on a playoff spot.
Alabama's quarterback may have played his final game for the Crimson Tide after suffering a dislocated hip on Saturday in the win over Mississippi State.
The Bulldogs' win over Auburn vaulted them into the No.4 spot, while LSU, Ohio State and Clemson remained in the top three.
Saturday's matchup in Waco could serve as the dress rehearsal for the Big 12 Championship Game and could determine both programs' CFP chances.
After winning the remake of the "Game of the Century," the No.1-ranked Tigers look to strengthen their gap on the SEC West.
Minnesota's win over undefeated Penn State vaulted it from No.17 to No.8 in the CFP rankings and the Gophers look to keep their undefeated run going against No.23 Iowa on Saturday.
The No.2-ranked Buckeyes travel to New Jersey as a whopping 52-favorite as they look to improve their record to 10-0.
No.4 ranked Georgia travels to Alabama looking to consolidate its playoff hopes, while No.12 ranked Auburn looks to keep its season alive.
The reigning national champions have secured a fifth consecutive divisional title and can move within one game of finishing a second straight regular season undefeated.
The Crimson Tide is in danger of missing out on the College Football Playoff for the first time in history after falling to No.5 in the CFP rankings.
The top three teams ranked by the College Football Playoff Committee -- LSU, Ohio State and Clemson -- were also the top choices in the poll.
Clemson is back in the top four, while Alabama could miss the playoffs and the Big 12 has work to do.
LSU is expected to claim the No. 1 spot in the CFP rankings, while Alabama could fall out of the top four after losing to the Tigers.
Following the 46-41 over Alabama LSU tops both polls and is expected to claim to the No.1 spot in the new set of College Football Playoff ranking on Tuesday.
The defending national champions were ranked at No.5 by the College Football Playoff committee and have no room for error.
Iowa travels to Wisconsin on Saturday in one of only three top-25 matchups in Week 11 of the college football season.