LSU, Ohio State, Clemson and Georgia should again make the top four of the CFP, while Oregon and UCLA are closing in on a playoff spot.
Alabama's quarterback may have played his final game for the Crimson Tide after suffering a dislocated hip on Saturday in the win over Mississippi State.
The Bulldogs' win over Auburn vaulted them into the No.4 spot, while LSU, Ohio State and Clemson remained in the top three.
Saturday's matchup in Waco could serve as the dress rehearsal for the Big 12 Championship Game and could determine both programs' CFP chances.
After winning the remake of the "Game of the Century," the No.1-ranked Tigers look to strengthen their gap on the SEC West.
Minnesota's win over undefeated Penn State vaulted it from No.17 to No.8 in the CFP rankings and the Gophers look to keep their undefeated run going against No.23 Iowa on Saturday.
The No.2-ranked Buckeyes travel to New Jersey as a whopping 52-favorite as they look to improve their record to 10-0.
No.4 ranked Georgia travels to Alabama looking to consolidate its playoff hopes, while No.12 ranked Auburn looks to keep its season alive.
The reigning national champions have secured a fifth consecutive divisional title and can move within one game of finishing a second straight regular season undefeated.
The Crimson Tide is in danger of missing out on the College Football Playoff for the first time in history after falling to No.5 in the CFP rankings.
The top three teams ranked by the College Football Playoff Committee -- LSU, Ohio State and Clemson -- were also the top choices in the poll.
Clemson is back in the top four, while Alabama could miss the playoffs and the Big 12 has work to do.
LSU is expected to claim the No. 1 spot in the CFP rankings, while Alabama could fall out of the top four after losing to the Tigers.
Following the 46-41 over Alabama LSU tops both polls and is expected to claim to the No.1 spot in the new set of College Football Playoff ranking on Tuesday.
The defending national champions were ranked at No.5 by the College Football Playoff committee and have no room for error.
Iowa travels to Wisconsin on Saturday in one of only three top-25 matchups in Week 11 of the college football season.
The two SEC rivals collide in the most anticipated match of the college football regular season on Saturday.
Two of the seven remaining undefeated teams in the FBS collide as the No.5-ranked Nittany Lions travel to Minnesota to take on No.13 Golden Gophers.
The Buckeyes look to improve to 9-0 after claiming top spot in the first College Football Playoff ranking of the season.
Saturday's "Game of the Century" in Tuscaloosa will have huge implications for both the SEC title and the College Football Playoff race.
In the last 11 seasons, Alabama has lost just four times at home during the regular season and is unbeaten in Tuscaloosa since 2015.
Alabama is a six-point favorite ahead, but LSU is 6-0 against the spread since Ed Orgeron took over as full-time head coach.
Being ranked No. 5 by the College Football Playoff Selection Committee hasn't dampened the Tigers' odds at several sportsbooks.
The College Football Playoff committee has Ohio State at No. 1 in its initial 2019 standing, and LSU-Alabama is not a 1-2 matchup anymore in the ranking that means the most.
The College Football Playoff Committee will release its first rankings of the year on Tuesday, November 6.
LSU and Alabama will officially be going into their eagerly-awaited clash next Saturday as the top-two ranked teams in college football.
No. 7-ranked Oregon travels to Los Angeles to take on the Trojans as it looks for an eighth consecutive win to keep its postseason hopes alive.
The reigning national champions look to improve their record for the season to 9-0 and extend their winning run to 24 games when they host Wofford.