Clemson looks to extend its winning streak to 20 games when it plays North Carolina on the road on Saturday.
The pick of the crop of the Week 4 games sees the No. 4-ranked Bulldogs host the No. 7-ranked Fighting Irish.
The defending national champions could extend their winning record to 19 games when they host the 49ers this weekend.
The Buckeyes should move to 4-0 this weekend, when they host Miami in their final nonconference game of the season.
The Tigers look to improve their season record to 4-0 when they take on the 0-2 Commodores in Nashville.
Alabama is 3-0 so far this season but coach Nick Saban is wary of the offensive threat posed by Southern Mississippi.
Tua Tagovailoa, Jalen Hurts and Joe Burrow have emerged as the runaway favorites for the award after the first three games of the season.
Week 4 features three matchups between Top-25 ranked teams, including a major test for Georgia, which takes on Notre Dame.
Jalen Hurts has set college football alight since transferring from Alabama to Oklahoma, and could add to his stellar return against UCLA.
Clemson could extend its winning streak to a school-record 18 games with a victory on the road against Syracuse.
Riding high after beating Texas on the road, the Tigers take on FCS program Northwestern State at home on Saturday.
Alabama looks to move to 3-0 for the season when it travels to South Carolina on Saturday.
The Buckeyes and the Hoosiers have both won their two opening games but for one team their perfect record will come to and end on Saturday.
Georgia looks to improve to 3-0 when it takes on the Red Wolves ahead of a testing run of games over the next five weeks.
No. 1-ranked Clemson travels to Syracuse, while No.2-ranked Alabama takes on South Carolina on the road.
The Sooners host a team from the FCS division for the first time in seven years as they look to move to 2-0.
The Bulldogs are a 48.5-point favorite when they take on the Racers on Saturday afternoon in their first home game of the season.
The Crimson Tide could rack up a huge score when it takes on the 55-point underdogs Aggies in its home debut on Saturday.
The defending champions look to extend their winning streak to 17 games and are heavy favorites against the Aggies.
The Buckeyes look to improve their record to 2-0 when they take on Ohio rivals Cincinnati Bearcats on Saturday afternoon.
Defending champion Clemson hosts No. 12 Texas A&M, while No. 2 Alabama and No. 3 Georgia take on New Mexico State and Murray State.
The post-Kyler Murray era begins on Sunday for the Sooners as they host the Cougars in their first game of the season.
The Bulldogs kick off their 2019 campaign on Saturday with a road game against Vanderbilt in Nashville.
Seven months on after losing to Clemson in the national title game, the Crimson Tide returns to action in the Chick-fil-A Kickoff Game.
The Ryan Day era at Ohio State gets underway on Saturday when the Buckeyes welcome Florida Atlantic in the first game of the season.
The Aggies are the 12th-ranked team in the country but face a very difficult schedule in Jimbo Fisher's second season in charge.
The defending national champions kick off their campaign against Georgia Tech in front of their own fans on Thursday.
The college football season begins in earnest on Thursday, and Clemson and Alabama again look favorites to go head-to-head for the national title.
Clemson begins the defense of its national title on Thursday when it hosts Georgia Tech, while Alabama opens its campaign on Saturday against Duke.
The 2019 college football season begins on Saturday for the FBS as the two Florida rivals collide in Orlando.