"I am confident that whoever wins the Republican primary next year will defeat the Democrat candidate in the general election for this seat, and I will do everything I can to make that happen," Perdue said.
"It is imperative that Republicans regain the majority in the U.S. Senate in 2022 to have a balanced government," Perdue tweeted Tuesday.
The Republican lost his Senate seat in January against Georgia's other new Democratic senator, Jon Ossoff.
"Although we won the general election, we came up short of Georgia's 50% rule, and now I want to congratulate the Democratic Party and my opponent for this runoff win," Perdue said.
The Democratic candidate said in a video address: "I thank the people of Georgia for electing me to serve you."
The Republican senators have rejected suggestions of defeat, insisting on taking a stand over the results should they see the need to.
Republican Georgia Senators Kelly Loeffler and David Perdue said Tuesday that the election could "come down to the difference of just a few votes in a few precincts across the state."
Georgia's Democratic U.S. Senate candidate Jon Ossoff may have had a slight advantage over incumbent Republican Sen. David Perdue among independent voters in the runoff election, according to exit polling.
Despite a massive wave in early voting, voter turnout had slowed by Tuesday, including in the conservative region that broke heavily for Trump.
A betting odds website gave Democratic Jon Ossoff a 64 percent implied chance of winning and Raphael Warnock an implied 56 percent of winning.
Georgia Republican Senators Kelly Loeffler and David Perdue said that Tuesday's runoff elections "could come down to the difference of just a few votes in a few precincts across the state."
Georgia voters will decide the balance of power in Congress in twin Senate runoff elections on Tuesday.
Amid relentless pressure from progressives, the president-elect shifted from his endorsement of no-check stimulus legislation. He now promises $2,000 stimulus checks—if Georgia Democrats win.
"I'll be here in about a year and a half campaigning against your governor," President Donald Trump said Monday in Georgia, "I guarantee you that."
E.W. Jackson said Georgia voters "will be bringing a curse" on the country if they elect the two Democratic Senate candidates.
Republican Sens. David Perdue and Kelly Loeffler are against Democrat challengers Jon Ossoff and Raphael Warnock for control of the U.S. Senate.
Both races are well within the margin of error as dueling campaign rallies from Joe Biden and Donald Trump are set to occur Monday in Georgia.
"What he [Trump] is saying, a lot of people in Georgia and 75 million Americans, I think, align with him right now that something untoward happened here in Georgia and we have not gotten to the bottom of it," Georgia Republican Senator David Perdue said on Monday.
On January 5, twin runoff Senate elections in Georgia will decide which party will control the U.S. Senate.
"I won't belabor it, but that's not a yes or no whether you would sustain the veto or not," Bret Baier told the GOP senator.
Democrat Ossoff told CNN his party were "on the cusp of a historic victory" on Sunday, while Perdue remains in quarantine and is expected to miss a rally featuring President Donald Trump this week.
Regardless of whether Perdue wins or loses his runoff on Tuesday, he cannot vote in the Electoral College count session in which at least 11 Republican senators said they would oppose Biden's victory.
Days before the Georgia runoffs, incumbent Republican Senator David Perdue released an op-ed attacking his opponent Jon Ossoff.
Georgia Senator David Perdue is in a tough re-election bid and with just days until the election, he's trailing Democratic challenger Jon Ossoff in polls.
GOP candidates Sens. Kelly Loeffler and David Perdue face off against Democratic challengers Raphael Warnock and Jon Ossoff on Tuesday.
Early voter turnout favored Black and traditionally Democratic areas, but Election Day numbers historically back the Senate Republicans.
Two runoff elections in Georgia on January 5 will decide control of the U.S. Senate for the next two years.
"Both Senator Perdue and his wife tested negative today, but following his doctor's recommendations and in accordance with CDC guidelines, they will quarantine," the Perdue campaign said.
"These seats are the last line of defense to save America and protect all that we have accomplished," President Donald Trump said at a December Republican campaign event.