West Virginia officials rejected Don Blankenship's attempt to appear on the U.S. Senate ballot in November.
Blankenship's surging popularity in the weeks leading up to the election threw the GOP into a panic.
"We have a three-alarm fire in West Virginia," said Republican strategist Ford O'Connell.
Don Blankenship hit headlines previously with his 'Cocaine Mitch' ad.
The candidate, who previously called McConnell's father-in-law a "Chinaperson," talks over a country melody in the political ad.
Blankenship was sentenced to a year in prison in 2015 for conspiring to break mine safety laws after an investigation into the deaths of 29 miners in 2010.
Former Massey Energy CEO sentenced to a year for role in 2010 explosion that killed 29.