The actor and artists slammed people supporting Trump after his "racism, misogyny, infidelity, environmental rape, and high treason."
The drawing is set for 11 p.m. EST Tuesday.
In South Carolina, the winner can remain anonymous.
There's a live stream and the numbers are added to the Mega Millions site shortly after they're drawn.
"Has Mad Dog Mattis become Lapdog Mattis? Are the brave men and women of our military now being used as extras in an expensive PR stunt...paid for by YOU?"
"Pull back the curtains and let the sunshine turn all those bloodsuckers to dust," Jim Carrey wrote on Twitter.
Accompanying his new political piece, Carrey wrote: "Make no mistake, these terrorists were encouraged and emboldened by the hate speech of Donald Trump."
Sanders was depicted in an unflattering drawing about Ivanka Trump closing her fashion line.
"I drew pictures like this. Any other person of this age drew drawings like this. It's nothing to get expelled from school for," the boy's father said.
"The painting is not very inspired—high school students have doodled better artworks during trig class."
A previous drawing by Trump sold in July for more than $29,000.
The Charlie Hebdo shooting highlighted the threats faced by editorial cartoonists, according to a new report.
An original ink drawing by E.H. Shepard sold at auction in London for nearly $500,000.