The veteran Democrat said African Americans were "quite aggrieved" by new voting restrictions across the country.
Former U.S. Senator Heidi Heitkamp labeled Gina Carano a "Nazi" on a talk show after the actress was fired from "The Mandalorian."
The ad, which ran in local newspapers across the state on Sunday as an attack against GOP opponent Kevin Cramer, reportedly misidentified women who were victims of sexual assault, domestic violence and rape.
The bill rolls back some regulations from the 2010 Dodd-Frank Act, which placed restrictions on banks in the wake of the financial crisis.
Both West Virginia's Manchin and North Dakota's Heitkamp are up for re-election next year in states that voted for Trump in the 2016 presidential election.
All but one Senate Republican on Thursday blocked a gun control measure to prevent suspected terrorists from buying weapons.