The Pittsburgh Steelers are in control of the AFC at 10-0, while the New Orleans Saints lead the NFC with a 8-2 record.
The veteran kicker has a career-worst 60 percent conversion rate on field goals this season and has missed eight kicks in nine weeks.
The Colts running back is the only NFL player this season to have multiple games with a receiving touchdown and a rushing touchdown.
Only Drew Brees, Tom Brady, Payton Manning and Brett Favre lead Rivers among all-time quarterbacks in one of the top statistical categories. Rivers passed Dan Marino on the Colts' first play Thursday night.
The Colts, Titans and Texans all begin the season with legitimate aspirations of winning one of the traditionally hardest NFL divisions to predict.
Jim Irsay had previously donated $1 million to a food bank in Indianapolis and challenged Colts fans to raise $200,000 for children whose parents have been affected by the job losses due to the virus.
Brees connected with Josh Hill early in the third quarter to give the Saints a 27-0 lead, and it made Brees the league's all-time leader in touchdown passes.
Manning, who played mostly for the Indianapolis Colts and then the Denver Broncos from a span of 1998-2015, still holds the record for most passing touchdowns in a career with 539. Drew Brees is third on the list with 537, and the Saints play at home Monday night.
The Saints can draw level with the Seattle Seahawks and the Green Bay Packers with a win, which would keep their chances of securing a first-round bye alive.
The two AFC South rivals both enter Week 12 with a 6-4 record ,and their matchup in Houston will have major implications for the playoffs picture.
Week 12 begins on Thursday night with a crucial AFC South matchup as the Houston Texans host the Indianapolis Colts.
The 32-year-old quarterback will hold a private workout organized by the NFL in Atlanta on Saturday, to which all 32 NFL teams have been invited.
The Patriots and the Chiefs look set to win their divisions, while the Chargers and Browns face a battle to reach the playoffs.
The Chiefs host the Colts in a rematch of last season's AFC Divisional Round Playoffs as they look to improve to 5-0.
The 100th NFL season gets underway on Thursday as the Chicago Bears host the Green Bay Packers at Soldier Field.
Luck was escorted toward the tunnel of Lucas Oil Stadium, where he was met by a paparazzi of cameras in front of him and chorus of boos from the crowd.
The news came unexpectedly, and as a shock, Saturday night as the 29-year-old quarterback who was once an overall top pick will call it quits.
The Indianapolis Colts are likely to be without Andrew Luck as they look to bounce back after losing to the Buffalo Bills last week.
The divisional round of the 2019 NFL playoffs gets underway on Saturday, January 12.
The Titans face the Colts in a winner-takes-all showdown, while three divisional titles are up for grabs in the AFC.
The league announced the salary cap range will be between $187 million and $191.1 million next season.
Police say the suspect had been deported twice before crashing his car into the woman's husband and NFL linebacker Edwin Jackson.
This really happened.