The group managed to escape from the jail after using a table to break open an exterior fire door.
The four inmates escaped Gallia County Jail in the very early hours of Sunday morning after they overpowered two corrections officers.
The notorious drug kingpin has previously escaped from two Mexican prisons.
Sunday's daring escape was the latest in a long history of audacious armed robberies and jail breaks by the 46-year-old career criminal.
The four men had been jailed on drug and fraud charges.
Four inmates escaped from hospitals or medical transports in the past two weeks, revealing what correctional experts say is a flawed system.