Foreign Minister Javad Zarif gave an interview in New York City, where he is under tight visa restrictions, during a visit to the United Nations.
President Donald Trump said Sunday Iran had "better be careful" with its expansion of enriched uranium production.
"That's a very serious issue if they continue to do that," Trump's national security adviser warned.
"We are actually considering escalating with Iran in a war that would further destabilize the region and unleash God knows what in terms of chaos in a very troubled region already," Elise Jordan said.
War could become a fait accompli if Trump keeps Bolton in the White House.
Washington has been at odds with Europe over Iran since the Trump administration abandoned the 2015 nuclear deal.
"War with Iran is playing with fire, and it will burn all, and not just Iran," said Iranian lawmaker Alaeddin Boroujerdi.
"They have all shown an interest in dragging the United States into a conflict," Javad Zarif told Fox News Sunday. "I do not believe that President Trump wants to do that. I believe that President Trump ran on a campaign promise of not bringing the United States into another war."
Iran's General Amir Hatami said President Donald Trump's policies have promoted "such traits as selfishness, cruelty and violation of humanitarian principles and international rules."
The 2020 Democrats have to bring back the deal.
The president "rejoices over the misery that he thinks he has imposed on ordinary Iranians," Iranian Foreign Minister Javad Zarif wrote on Twitter.
"No one can defeat a nation which pursues resistance," Iranian President Hassan Rouhani said in a televised address, claiming the U.S. and its allies were to blame for the country's poor economy.
Ayatollah Ahmad Khatami pointed out that nuclear bombs are "clearly" against Islamic (or Sharia) law.
"Iraq's constitution does not allow our territory of our country to be used against our neighbors," President Barham Salih said.
The new special purpose vehicle for trade with Iran could keep the nuclear deal until 2020, experts argue.
"We continue to assess that Iran is not currently undertaking the key nuclear weapons-development activities we judge necessary to produce a nuclear device," Dan Coats said.
"The misbehavior of the U.S. government indicates that the U.S. does not abide by any principles protecting rights of those criticizing the system," Iranian Foreign Ministry spokesman Bahram Qasemi said of the U.S. arrest of a black Muslim American journalist who works for Iran's Press TV.
"It definitely rattled people," a former senior U.S. administration official told The Wall Street Journal. "People were shocked. It was mind-boggling how cavalier they were about hitting Iran."
"The Americans happily say that these sanctions are unprecedented in history. Yes, they're unprecedented. And the defeat that the Americans will face will be unprecedented, God willing," Supreme Leader Ayatollah Ali Khamenei said.
"The United States is a regime formed on the basis of capitalism, racial discrimination and hegemonism," Major General Mohammad Ali Jafari said.
Economy Minister Bruno Le Maire also stressed that tensions with the U.S. over Iran revealed the need for the EU to "affirm our independence."
"We will not obey such sanctions," Turkish President Recep Tayyip Erdogan said, adding that his government saw Washington's move as "violating the global balance."
"U.S. bullying is backfiring," Foreign Minister Javad Zarif warned earlier on Monday.
"We are in the economic war situation," Iranian President Hassan Rouhani warned as new U.S. sanctions took effect. "We are confronting a bullying enemy."