As progressives demand passage of the $3.5 trillion package in tandem with the bipartisan $1.2 trillion infrastructure bill, nine moderates are urging the opposite.
Manchin joined 49 Republicans in voting for the amendment, which passed early Wednesday.
A budget resolution for the spending package needs to be passed before lawmakers can begin drafting a larger bill that would detail tax and spending plans.
The South Carolina Republican revealed he had tested positive for COVID-19 on Monday but had mild symptoms.
"Are we still going to be competitive? Can we compete in a global market?" the Democratic senator asked.
Democratic Sen. Joe Manchin previously said he would not vote to "weaken or eliminate the filibuster."
The moderate Democrat from West Virginia finished the second quarter of 2021 with more than $3.9 million of cash on hand.
"We're going to continue to push. We're going to have hearings. We're going to have votes until we get this done," the Democratic Senate Majority Leader said.
The moderate West Virginia Democratic senator said "we're getting close" in reference to the bipartisan infrastructure plan.
Sen. Joe Manchin (D-W. Va.) was reportedly headed to a Texas fundraising event hosted by Republican donors from the oil industry two days after saying that a Democratic plan to eliminate fossil fuels would make climate change "worse."
"They want to get rid of [fossil fuel], and thinking that's going to clean up the global climate, it won't clean it up all. If anything, it would be worse," Manchin said.
The moderate Democratic senator said he was "very, very disturbed" by some provisions in the massive spending package.
The budget could possibly pass through the upper congressional chamber without needing approval from any of the Senate's 50 Republican members.
Keith McCoy, a senior lobbyist for ExxonMobil, was covertly filmed claiming the oil giant is secretly fighting legislative attempts to tackle climate change. The company has denied this.
"President Biden...is anxious for this bill to pass and for him to sign it. And I look forward to being there when he does," said Manchin about the infrastructure legislation.
"We came to an agreement on a plan that we have and we're just going to try to wrap it up tomorrow," Manchin told reporters.
All 50 members of the Senate Democratic caucus voted in favor of the bill, including Democratic West Virginia Senator Joe Manchin who was considered a lone holdout.
"I've found common ground with my Democratic colleagues on a new version of the bill that ensures our elections are fair, accessible and secure," Manchin said in a statement.
The moderate senator wants assurances his amendments will be incorporated before committing to support the For the People Act.
"As you know, the Constitution does provide for federal oversight of state elections," the Fox News Sunday anchor told the GOP senator.
U.S. Sen. Joe Manchin met with a group of Texas Democrats Thursday evening who blocked a state law there that would put new restrictions on early voting.
"What Sen. Manchin is putting forward are some basic building blocks that we need to ensure that democracy is accessible no matter your geography," Abrams told CNN.
U.S. Sen. Joe Manchin, a West Virginia Democrat who has been a roadblock for Democrats who want to pass sweeping voting legislation, missed out on a meeting with a group of Democrats from the Texas Legislature on the topic this week—sending top aides in his place.
On a private call on Monday, Manchin suggested he would be willing to change the Senate rules so Senate Democrats could pass legislation with fewer than the 60 votes currently required by the filibuster.
The New York progressive suggested efforts at bipartisan compromise allow policy to be "defined by a Republican minority that has not been elected to lead."
Manchin penned an op-ed in the Charleston Gazette-Mail last week, which explained bluntly "why I'm voting against the For the People Act."
West Virginia Governor Jim Justice backed the Democratic senator for blocking moves to scrap the Senate rule.
"I urge my colleagues on both sides of the aisle to support this commonsense bill to ensure a level playing field for everyone, including our top-notch U.S. Women's National Soccer Team," West Virginia Senator Joe Manchin said on Wednesday.
"Dems are burning precious time & impact negotiating w/GOP who won't even vote for a Jan 6 commission. McConnell's plan is to run out the clock," the progressive firebrand tweeted on Wednesday. "It's a hustle. We need to move now."