The 34-year-old won the World Cup in July and was named player of the tournament, before adding the FIFA World Player of the Year in September and the Ballon d'Or last month.
The Blaugrana could momentarily open a three-point lead over Real Madrid when they take on Leganes on the road in the early kick-off on Saturday.
The Catalans are on a two-game winless streak in all competitions and their coach is under severe pressure.
The Blaugrana look for a sixth consecutive win in La Liga when they travel to Valencia on Saturday afternoon.
After an unexpected weekend off because of El Clasico's postponement, Barcelona can go back to the top of La Liga when it plays Valladolid on Tuesday.
The five-time European Cup winners look to extend their lead at the top of Group F when they take on Slavia Prague.
Barcelona looks to make it four wins in a row when it takes on Eibar on Saturday but the focus will likely be on pro-Catalonia protests.
Barcelona looks to extend its winning run to three games, while Sevilla searches for a first win at the Camp Nou since 2002.
Lionel Messi could make his first start this season when Barcelona travels to Granada on Saturday looking for a second consecutive win.
Lionel Messi could make his first appearance of the season when Barcelona travels to Germany to face Dortmund on Tuesday.
Barcelona looks to shake off a difficult start to the season when it takes on Valencia this Saturday afternoon.
The defending La Liga champions look for a second consecutive win against Osasuna in Pamplona on Saturday.
The defending La Liga champions look to get their campaign back on track after losing to Athletic Bilbao in the first game of the season.
Argentina was eliminated by Brazil in controversial fashion, while Chile's bid for a third consecutive title came to an end against Peru.
Brazil and Argentina renew their rivalry in the semifinals, while Chile takes on Peru hoping to reach the final for the third time in a row.
Brazil and Argentina square off on Tuesday night for a place in the final, while Chile plays Peru on Wednesday.
Brazil takes on Paraguay in the quarter-finals, while Argentina faces Venezuela and the two rivals could meet in the semi-finals.
Brazil is a heavy favorite against Paraguay, while Argentina faces a tricky test against Venezuela on Friday.
Argentina vs Colombia is the first heavyweight clash of the tournament, while Chile vs Uruguay could be crucial.
The 46th edition of the tournament gets underway on Friday and promises to be one of the most even in years.
Brazil hosts the Copa America this year but has not won the tournament in 12 years and will be without Neymar.
"In the Argentina against Iceland game we saw just how much Messi needed the warm-up game against Israel."
The 411 on this summer's biggest sporting event.
The campaign will see 10,000 school meals donated each time Neymar or Messi score at this World Cup.
Ernesto Valverde's team is marching toward the title in his first season in charge at the Nou Camp.
In seven meetings in La Liga, Barcelona has beaten Eibar each time and scored 26 goals.