The Patriots travel to Miami in what could be a hopelessly lopsided game, while Cleveland must turn things around on Monday night on the road against the Jets.
The 100th NFL season gets underway on Thursday as the Chicago Bears host the Green Bay Packers at Soldier Field.
The two NFC rivals meet in Honolulu, Hawaii, on Saturday night as they look to fine-tune their preparations for the upcoming season.
Week 2 of the NFL preseason begins Thursday night with eight games nationally broadcast over the following four days.
The Oakland Raiders and the Denver Broncos have the toughest schedule of any of the 32 NFL franchises this season.
The New England Patriots, Los Angeles Rams, Kansas City Chiefs and Philadelphia Eagles will feature three times each on Sunday Night Football.
The New England Patriots and the Kansas City Chiefs are the bookmakers' favorites, followed by the Los Angeles Rams and the New Orleans Saints.
Week 1 of the NFL season sees the New Orleans Saints hosting the Houston Texans and the Oakland Raiders welcoming the Denver Broncos.
The Patriots had never won a Super Bowl by more than six points until Sunday.
The Chiefs are 6-1 favorites to win the Super Bowl next year, while the Patriots and the Rams are both 8-1.
The Patriots are 2.5-point favorite going into Super Bowl LIII.
Sunday night marks the 53rd playing of the Super Bowl.
Neither Los Angeles nor New England reported ay injuries ahead of Sunday's game in Atlanta.
Tom Brady could become the first player in NFL history to win six Super Bowl rings.
Brady will become the oldest quarterback to win the Super Bowl if the Patriots beat the Rams on Sunday.
The Patriots quarterback told a young fan he "loves the haters" and "wishes them the best."
The no-call cost the Saints a shot at reaching Super Bowl LIII and completely overshadowed the outcome of the game.
Lawsuits against NFL and commissioner Roger Goodell want game to be replayed.
Bookmakers have the New England quarterback at even odds to win an unprecedented fifth Super Bowl MVP award.
Championship Sunday sees the Rams travel to New Orleans, while the Chiefs host the New England Patriots.
The Titans face the Colts in a winner-takes-all showdown, while three divisional titles are up for grabs in the AFC.
The Houston Texans and the Seattle Seahawks will be in the postseason, but Pittsburgh's season is almost over.