The two Los Angeles rivals square off on Sunday in the second derby of the season, with LAFC looking to avenge its 3-2 defeat from last month.
The two New York rivals go head-to-head on Saturday with both teams looking to consolidate their playoff chances.
The Mexican took his goal tally for the season to 26 with a brace against San Jose, which included a stunning finish.
Atlanta takes on the Timbers on the back of a four-game winning streak and fresh from winning its first continental trophy.
The Western Conference rivals desperately need to find some form after winning just two of their last eight games combined.
The second and third team in the Eastern Conference standings go head-to-head in Atlanta this Sunday.
The MLS All-Stars will be looking for a first win since 2015 when they take on the Spanish giants Wednesday.
The Timbers look to extend their unbeaten run to six games, while the Galaxy must find some consistency.
Los Angeles FC takes on the defending champions on Friday night as it looks to rebound from a defeat in El Trafico.
New York City FC hosts Sporting Kansas at Yankee Stadium on Friday night looking for a second consecutive win.
The fiercest rivalry in U.S. soccer returns on Sunday night as the Seattle Sounders host the Portland Timbers.
The first El Trafico of the season takes place on Friday night, as the Galaxy host Western Conference leaders LAFC.
Bheem Goyal is fighting leukaemia and was "signed" to a contract with the Sounders in partnership with the Make-A-Wish foundation.
Inter Miami CF and the MLS are involved in a legal dispute with Italian giants Inter Milan over the use of the word "inter."
The MLS season gets underway this weekend with Philadelphia Union hosting Toronto FC on Saturday at 1 p.m. ET.
Who is going where this summer?
Who's going where in English football biggest league?
Schweinsteiger was frozen out by José Mourinho.
Schweinsteiger will move to MLS on a one-year contract.
Schweinsteiger is moving to MLS side Chicago Fire.
The Major League Soccer teams played each other on Sunday.
Lampard played under Mourinho at Stamford Bridge.