The mosquitoes are being released as part of an experiment to help combat a disease-transmitting local species, according to Oxitec, the company behind the project.
Triple E is a rare but deadly disease, with a 33 percent fatality rate in humans and 90 percent fatality rate among horses.
Farmers in the state have lost hundreds of cattle due to the massive insect swarms, which arrived after Hurricane Laura brought heavy rainfall to the area.
The project is a first for the U.S.
While eastern equine encephalitis is a rare disease, around 30 percent of patients die and others will suffer ongoing neurological problems.
There have 21 reported cases nationwide this year and three deaths in Michigan alone. With no known vaccine or treatment, health officials are encouraging those in affected areas to avoid being bitten.
"Tracking and monitoring the types of mosquitoes that exist in Nebraska communities is critical, which in turn helps us identify potential public health implications and implement prevention measures to reduce risk," a state epidemiologist said.
Reports of mosquitoes three times bigger than normal emerged soon after Hurricane Florence passed.
A gene drive to stop the spread of malaria showed promise, with no mutations arising in laboratory experiments.
There is no vaccine to prevent infection, and there are no medications to treat the virus in people.
The mosquitoes were infected with a unique bacteria.
One of the world's most dangerous pests, this mosquito species infects millions with disease around the world each year.
Mosquito saliva may be increasing the severity of diseases.
Pitting mosquitoes against mosquitoes just might work.
Aerial spraying of insecticides should help to kill the bugs, but officials caution residents to stay inside during spraying.
Sometimes summer really bites.
The fungus can penetrate Aedes aegypti larvae when suspended in water.
Professor says more research is needed to know whether the higher rate of autism is due to spraying itself or higher exposure to mosquito-borne illnesses.