The National Debt totals over $28 trillion, and Joe Manchin has said he does not want Biden's bill to make things worse.
"If we're going to solve problems facing the American people, we have to be able to work together," said the Democratic senator from Delaware.
The Senate is scheduled to vote Wednesday on whether to take up a bill to suspend the debt limit.
Treasury Secretary Janet Yellen has warned the U.S. will not be able to fulfill its commitments by October 18.
Critics of the Senate infrastructure plan have cited the growing debt and burden that the increased national debt puts on American households.
"There's not a great track record of Republicans recently to tout themselves as deficit/debt hawks," Bret Baier told the Florida GOP lawmaker.
"The leader's statements on debt ceiling are shameless, cynical and totally political," said Senate Majority Leader Check Schumer.
The best evidence available today shows that the growing national debt contributes to massive problems that many on the Left and Right care about.
Even when personal profit was not involved, earmarks were about buying votes.
The Utah Republican highlighted that under GOP leadership the U.S. was "adding almost a trillion dollars a year to the national debt."
In an age of unprecedented government spending and debt—and unconstitutional government power and control—more members of Congress become millionaires while in office than ever before.
Trump promised to "get rid" of the national debt during his 2016 presidential campaign.
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Whether the GOP opposition is led in the upcoming years by President Trump or one of the party's next generation of conservative leaders like Senator Hawley, its future lies in a populist program.
The national debt has doubled thanks in no small part to efforts to alleviate the impact of the economic lockdown used to prevent the disease from spreading.
The coronavirus pandemic has roiled the markets, tossed most fiscal assumptions to the wind and driven the national debt to the highest level since World War II, as the government spent heavily to support the economy.
American higher education needs a wrecking ball—not a bailout.
"He said he was a fiscal conservative, but he's one of the biggest spenders in Congress," the group said about the Republican South Carolina senator in a new ad.
Although trillions have been spent to address the economic fallout of the COVID-19 pandemic, the debt increased substantially during Trump's first three years as well.
The treasury secretary said the national debt won't be dealt with until after the COVID-19 pandemic.
The Congressional Budget Office estimates that the federal debt will exceed 100 percent of GDP in 2021.
The swelling amount is at odds with Trump's promises before he was elected, when he said he would eliminate the nation's debt "over a period of eight years."
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A portion of that increase is tied to the CARES Act, passed by Congress to give Americans supporting during the ongoing novel coronavirus pandemic.