In the last 11 seasons, Alabama has lost just four times at home during the regular season and is unbeaten in Tuscaloosa since 2015.
Alabama is a six-point favorite ahead, but LSU is 6-0 against the spread since Ed Orgeron took over as full-time head coach.
The College Football Playoff Committee will release its first rankings of the year on Tuesday, November 6.
LSU and Alabama will officially be going into their eagerly-awaited clash next Saturday as the top-two ranked teams in college football.
No. 7-ranked Oregon travels to Los Angeles to take on the Trojans as it looks for an eighth consecutive win to keep its postseason hopes alive.
The reigning national champions look to improve their record for the season to 9-0 and extend their winning run to 24 games when they host Wofford.
The No.6 ranked Gators take on the No.8 ranked Bulldogs on Saturday in a matchup with crucial implications for the College Football Playoff race.
No. 12 Baylor returns from its bye week as one of the only nine teams left undefeated in the FBS and will look to improve to 8-0.
"Talk to me @EASPORTS. When can we get this started?!? #BringBackNCAAFootball," Kirk Herbstreit, a college football analyst for ESPN, tweeted shortly after the NCAA's announcement.
The Tigers climbed to No. 1 for the first time this season after beating Auburn 23-20, while Oklahoma dropped five spots to No. 10.
The Fighting Irish travel to Michigan looking for a first in Ann Arbor in 14 years to keep their playoffs hopes alive.
The Crimson Tide could improve to 8-0 with a win over Arkansas, but that may not be enough to hold onto the No. 1 spot.
Clemson hopes to halt its slide down the rankings and improve to 8-0 against its ACC Atlantic rivals on Saturday.
The Tiger Bowl could shape the playoffs run in the SEC, as No.9-ranked Auburn hosts No. 2 LSU on Saturday.
A Big Ten matchup with potential huge playoffs implications pits the best defense in the nation against one of the most explosive offensive units in the country.
Ohio State jumped to No. 3 in the AP poll in Week 8, while Alabama and LSU retained the first two spots.
The No.1-ranked Crimson Tide looks to extend its record to 7-0 when it hosts the Volunteers on Saturday.
The two Big Ten rivals collide in State College on Saturday, with No. 7 ranked Penn State looking to consolidate its playoff chances, while No.16 ranked Michigan has still a shot at the postseason.
Following a potential season-defining loss to South Carolina, the Bulldogs look to get back to winning ways against Kentucky.
The defending champions have dropped to No. 3 in the rankings and look to climb back in the top two when they play Louisville in Week 8.
A week after beating Florida and climbing to No. 2 in the AP Top 25 poll, the Tigers look to improve their record to 7-0.
Fresh from defeating Texas in the Red River Showdown, the Sooners take on another Big 12 rival when they host West Virginia on Saturday.
Ohio State looks to improve to 7-0 when it takes on Northwestern in a rematch of last year's Big Ten Championship Game.
Top-ranked Alabama hosts Tennessee, while No. 2 ranked LSU and No. 3 ranked Clemson are on the road in Week 8.
The No. 5 and No. 7 teams in the nation meet on Saturday in a game that could have huge implications for the SEC.
The No. 10 ranked Nittany Lions take their dominant defense to Iowa City as they look to improve to 6-0 against the No. 17 ranked Hawkeyes.
The No. 3 ranked Bulldogs look to improve to 6-0 when they take on SEC East rivals South Carolina on Saturday.
The No. 1 ranked team in the nation returns from a bye as it looks to improve to 6-0 when it takes on the No. 24 ranked Aggies.