A week after beating Florida and climbing to No. 2 in the AP Top 25 poll, the Tigers look to improve their record to 7-0.
Fresh from defeating Texas in the Red River Showdown, the Sooners take on another Big 12 rival when they host West Virginia on Saturday.
Ohio State looks to improve to 7-0 when it takes on Northwestern in a rematch of last year's Big Ten Championship Game.
Top-ranked Alabama hosts Tennessee, while No. 2 ranked LSU and No. 3 ranked Clemson are on the road in Week 8.
The No. 5 and No. 7 teams in the nation meet on Saturday in a game that could have huge implications for the SEC.
The No. 10 ranked Nittany Lions take their dominant defense to Iowa City as they look to improve to 6-0 against the No. 17 ranked Hawkeyes.
The No. 3 ranked Bulldogs look to improve to 6-0 when they take on SEC East rivals South Carolina on Saturday.
The No. 1 ranked team in the nation returns from a bye as it looks to improve to 6-0 when it takes on the No. 24 ranked Aggies.
The two ACC rivals return from a Week 6 bye with Clemson looking for a 21st consecutive win when it hosts the Seminoles.
The Red River Showdown takes place in Texas this season, with the 4-1 Longhorns hosting the 5-0 Sooners.
Clemson and Alabama are back in action this weekend after a bye in Week 6 in a jam-packed weekend featuring five meetings between Top 25-ranked teams.
Two top-25 ranked teams meet in Ohio on Saturday, with the No.4-ranked Buckeyes looking to improve to 6-1
The two SEC rivals meet in Tennessee on Saturday with Georgia looking to gain the upper hand in the all-time series.
LSU looks to extend its winning streak to five games when it hosts the Utah State Aggies on Saturday afternoon.
The No. 6-ranked Sooners take their high-octane offense to Kansas on Saturday as they look to improve to 5-0.
Two of college football's historic rivals meet on Saturday in Florida both looking to consolidate their top-10 rankings.
Clemson looks to extend its winning streak to 20 games when it plays North Carolina on the road on Saturday.
The pick of the crop of the Week 4 games sees the No. 4-ranked Bulldogs host the No. 7-ranked Fighting Irish.
The defending national champions could extend their winning record to 19 games when they host the 49ers this weekend.
The Buckeyes should move to 4-0 this weekend, when they host Miami in their final nonconference game of the season.
The Tigers look to improve their season record to 4-0 when they take on the 0-2 Commodores in Nashville.
Alabama is 3-0 so far this season but coach Nick Saban is wary of the offensive threat posed by Southern Mississippi.
Tua Tagovailoa, Jalen Hurts and Joe Burrow have emerged as the runaway favorites for the award after the first three games of the season.
Week 4 features three matchups between Top-25 ranked teams, including a major test for Georgia, which takes on Notre Dame.
Jalen Hurts has set college football alight since transferring from Alabama to Oklahoma, and could add to his stellar return against UCLA.
Clemson could extend its winning streak to a school-record 18 games with a victory on the road against Syracuse.
Riding high after beating Texas on the road, the Tigers take on FCS program Northwestern State at home on Saturday.
Alabama looks to move to 3-0 for the season when it travels to South Carolina on Saturday.
The Buckeyes and the Hoosiers have both won their two opening games but for one team their perfect record will come to and end on Saturday.
Georgia looks to improve to 3-0 when it takes on the Red Wolves ahead of a testing run of games over the next five weeks.