No. 1-ranked Clemson travels to Syracuse, while No.2-ranked Alabama takes on South Carolina on the road.
The Sooners host a team from the FCS division for the first time in seven years as they look to move to 2-0.
The Bulldogs are a 48.5-point favorite when they take on the Racers on Saturday afternoon in their first home game of the season.
The Crimson Tide could rack up a huge score when it takes on the 55-point underdogs Aggies in its home debut on Saturday.
The defending champions look to extend their winning streak to 17 games and are heavy favorites against the Aggies.
The Buckeyes look to improve their record to 2-0 when they take on Ohio rivals Cincinnati Bearcats on Saturday afternoon.
Defending champion Clemson hosts No. 12 Texas A&M, while No. 2 Alabama and No. 3 Georgia take on New Mexico State and Murray State.
Seven months on after losing to Clemson in the national title game, the Crimson Tide returns to action in the Chick-fil-A Kickoff Game.
The two powers from the Sunshine state will kickoff college football's 150th season Saturday in Orlando.
The 20-year-old announced on Twitter he was transferring to the Hurricanes.
15 players on the roster on opening weekend came through the same Florida high school.
The Aggies led Texas, Florida and Alabama in the list.
Alabama visited the White House after winning the College Football Playoff National Championship in January.