Clemson is the biggest-favorite of any of the FBS teams in action in a conference championship game this week.
Championship Week begins on Friday night, when Utah and Oregon collide for the Pac-12 title, with a further nine games scheduled for Saturday.
The top four is expected to remain unchanged going into Championship Week, but Alabama should fall down the rankings after losing to Auburn in the Iron Bowl.
No major changes are expected in the top four of the latest CFP rankings, but Alabama is set to fall away after losing to Auburn in the Iron Bowl.
Utah and Oregon kick off Championship Week when they meet in the Pac-12 title decider on Friday, with LSU facing Georgia in the SEC title game on Saturday.
The No. 7-ranked Sooners take on state rivals and No. 21-ranked Cowboys needing a win to keep their College Football Playoff hopes alive.
No. 2 ranked LSU can go 12-0 with a win over the Aggies and avenge last season's controversial loss after seven overtimes.
The Bulldogs can improve to 11-1 and extend their winning run over the Yellow Jackets to three games on Saturday.
No. 1 Ohio State travels to No. 13 Michigan on Saturday looking to extends its winning streak over the Wolverines to eight.
No. 5-ranked Crimson Tide must win on the road against the No. 15 Tigers to keep its hopes of a spot in the College Football Playoff alive.
The No. 3-ranked Tigers are 11-0 and could go unbeaten in the regular season for a second consecutive year.
No. 1 Ohio State faces No. 13 Michigan on the road, while No. 5 Alabama takes on No. 15 Auburn in the Iron Bowl and No. 7 Oklahoma faces No. 21 Oklahoma State,
Ohio State leapfrogged LSU at No. 1, while Clemson and Georgia rounded up the top four and Utah climbed up to No. 6.
"With this decision, you have proven once again why your organization has become a national laughingstock and detriment to college sports and student athletes."
LSU, Ohio State and Clemson are set to retain the top three spots but Georgia's No.4 ranking could be in jeopardy.
LSU, Ohio State and Clemson are expected to retain the top three spots, while Utah could climb up to sixth.
The final week of regular season features a number of potentially crucial games, with Auburn taking on Alabama in the Iron Bowl and Ohio State traveling to Michigan.
Oklahoma climbed up two spots to No.8 in the latest CFP ranking after a spirited comeback against Baylor put in control of the conference.
The Tigers are 44-point favorite against the Razorbacks, the biggest point spread in SEC games in the last four decades.
Georgia has already clinched the SEC East title and a win against the Aggies would further consolidate its hopes of reaching the College Football Playoff.
The No.2-ranked Buckeyes host the No.9-ranked Nittany Lions in the de-facto title decider in the Big Ten East.
After losing its star quarterback to a season-ending injury, No.5-ranked Alabama has two games to force its way into the CFP top four.
On Thursday, ESPN analyst and former NBA player, Jay Williams posted a Twitter video supporting a GoFundMe campaign to help Memphis center James Wiseman pay an $11,500 charity donation required by the NCAA.
The amount equals what the star player's family received in moving expenses from a booster, who is now the head coach where Wiseman plays college basketball.
The Crimson Tide remained at No.5 in the latest set of CFP rankings, with LSU, Ohio State, Clemson and Georgia occupying the first four spots.
The CFP selection committee will release its latest set of rankings on Tuesday evening at 7 p.m. ET during its traditional show on ESPN.
LSU, Ohio State, Clemson and Georgia should again make the top four of the CFP, while Oregon and UCLA are closing in on a playoff spot.
Alabama's quarterback may have played his final game for the Crimson Tide after suffering a dislocated hip on Saturday in the win over Mississippi State.
The Bulldogs' win over Auburn vaulted them into the No.4 spot, while LSU, Ohio State and Clemson remained in the top three.
Alabama quarterback Tua Tagovailoa was injured in the second quarter of Saturday's game against Mississippi, after recovering from a sprained ankle in October.