Biden has the most diverse cabinet yet and has confirmed all 15 secretaries, but one cabinet-level position remains undecided 100 days into his presidency.
Days after Neera Tanden withdrew her nomination, Colin Kahn became the second of Joe Biden's administration picks to be grilled by senators over his past tweets.
The White House has not yet named a new nominee, but Young would be the first woman of color to hold the position.
"I think our country would be served well by Shalanda Young," said Michigan Representative Rashida Tlaib.
"It now seems clear that there is no path forward to gain confirmation, and I do not want continued consideration of my nomination to be a distraction from your other priorities," Tanden wrote.
Tanden, who would be the first South Asian woman to lead OMB, has been under fire over her past tweets and comments aimed at lawmakers.
The Office of Management and Budget director nominee will not be confirmed unless a GOP senator breaks with the party.
Governor Gavin Newsom's former chief of staff continues to back fellow Democrat Neera Tanden for OMB director, despite speculation she'll be tapped to replace her.
"My advice would be to not lose any more political capital than you already have, don't go to the mat for it, because this is one of several really important appointments that you need to get in place quickly," Kathryn Dunn Tenpas told Newsweek.
A vote against Biden's nominee from the Arizona senator would prevent Tanden's confirmation as head of the Office of Management and Budget.
Progressives are mounting a campaign to have longtime congressional aide Shalanda Young elevated from deputy director of OMB to the top position.
The delay comes after several senators said they would vote against the nominee, citing her previous comments about lawmakers.
Joe Manchin is one of several senators to publicly state opposition to Neera Tanden's nomination to be director of the Office of Management and Budget.
Biden will need to move quickly if the Senate votes against her. Here are six potential candidates to take Tanden's place.
The White House press secretary has again described Neera Tanden as an "accomplished policy expert," after lawmakers have come out in opposition to her nomination.
A spokesperson for Romney said the Utah senator "believes it's hard to return to comity and respect with a nominee who has issued a thousand mean tweets."
There has been opposition to Neera Tanden due to previous social media posts in which she targeted lawmakers.
Sen. Joe Manchin (D-W. Va.) announced that he opposes President Joe Biden's nomination of Neera Tanden to lead the Office of Management and Budget on Friday, warning that Tanden's confirmation could be "toxic" due to her history of "overtly partisan statements."
Tanden has come under fire in recent weeks for her combative Twitter history that included targeting Republicans and progressive Democrats.
"There were vicious attacks against progressives, people who I have worked with, me personally," Sanders told Tanden during her confirmation hearing.
Many former Bernie Sanders staffers have blasted President-elect Joe Biden's Cabinet pick of Neera Tanden, who they claim would work against progressive policies. Sanders himself has remained silent on Tanden's nomination.
"If you want to make sure this nutjob Tanden doesn't become the director of the budget, in charge of the Office of Management and Budget, then make sure we win in Georgia," Sen. Lindsey Graham (R-S.C.) said during a Monday night appearance on Fox News.
As Senate Republicans characterize Neera Tanden as "radioactive" and urge Biden to withdraw her nomination for head of the White House budget office, key GOP lawmakers signal they might not even hold confirmation hearings for her, much less confirm her.
Tanden, who's expected to be named as Biden's OMB director, is a divisive figure among some Democrats and an outspoken critic of Senate Republicans.
Two people were killed last week when an Islamic extremist launched a knife attack in central London.