New Orleans is the only team to have qualified for the playoffs so far, but Baltimore, New England, Kansas City, San Francisco and Seattle can join it on Sunday.
The remaining schedule includes a slew of games that will go a long way to determine not only which teams make the playoffs, but playoff seedings and home teams as well.
The Baltimore Ravens took control of the AFC with a 20-17 over San Francisco, which saw the 49ers slip to fifth in the NFC.
New England could qualify for the playoffs for the 11th consecutive season with a win in Houston, as long as the Raiders fail to beat the Chiefs.
The 10-1 Patriots lead the AFC with a one-game gap over the Ravens and both are 3/1 favorites to be celebrating in Miami in February.
The New Orleans Saints became the first team to clinch a playoff spot this season with a 26-18 win over the Atlanta Falcons on Thanksgiving.
Week 13 features three games on Thanksgiving Day, while the New England Patriots face the Texans in Houston on "Sunday Night Football."
Some Cowboys players are getting past the flu, some are in the beginning stages and quarterback Dak Prescott is taking preventative medications.
On Tuesday the wide receiver apologized to New England owner Robert Kraft for calling him out on Twitter after he was released in September.
The Cowboys have a 6-4 record, and only one team they've beaten seems to have a realistic shot at the playoffs. Of their four losses, three of them are making a strong playoff push. Then there was a bad loss.
The 32-year-old quarterback will hold a private workout organized by the NFL in Atlanta on Saturday, to which all 32 NFL teams have been invited.
The Patriots and the Ravens are in control of the AFC, while the race for the NFC has got tighter after Seattle beat San Francisco on Monday Night Football.
This comes on the heels of a since-deleted, expletive-laced tweet Thursday in which he said he would not play in the league again.
The reigning Super Bowl champions are 8-0 for only the third time in franchise history but face their hardest test of the season to date.
NFL teams can trade up to 4 p.m. ET on Tuesday, when trading stops until March 18 next year.
Week 9 of the NFL begins on Thursday when the San Francisco 49ers look to make it 8-0 when they take on the Cardinals in Arizona.
The Patriots travel to New Jersey hoping to extend their winning start to 7-0, while the Jets look for a second consecutive win.
Week 6 of the NFL regular season kicks off on Thursday night, when the Patriots host the Giants in Foxborough looking to improve to 6-0.
The Patriots and the Chiefs look set to win their divisions, while the Chargers and Browns face a battle to reach the playoffs.
The Patriots are 5-0 for the first time since 2015 and could find themselves going into the Week 10 bye at 9-0.
Week 6 of the NFL regular season kicks off on Thursday when the New York Giants travel to New England to face the Patriots.
The Patriots placed their kicker on injured reserve on Wednesday and have tried out a number of replacements since.
The New England Patriots released Antonio Brown on Friday after the wide receiver was accused of raping his former trainer last week.
Troubled wide receiver was expected to make his debut for the Patriots in Week 2 after signing a one-year deal on Monday.
A lawsuit filed in Florida claims Brown sexually assaulted his female trainer twice in 2017 and then raped her in 2018.
The Patriots travel to Miami in what could be a hopelessly lopsided game, while Cleveland must turn things around on Monday night on the road against the Jets.
The Patriots begin their quest for a seventh Super Bowl ring when they host the Steelers in Foxborough on Sunday night.
Antonio Brown has made headlines all offseason, and not for anything he has done on a football field. It's what has happened off of it, especially within the last week.
The traditional long-hour documentary celebrating the most recent Super Bowl winners premieres at 9 p.m. ET on Wednesday.