Both the Saints and the Chargers lost their first preseason games and will be looking to bounce back on Sunday.
The New England Patriots and the Kansas City Chiefs are the bookmakers' favorites, followed by the Los Angeles Rams and the New Orleans Saints.
Week 1 of the NFL season sees the New Orleans Saints hosting the Houston Texans and the Oakland Raiders welcoming the Denver Broncos.
Ezekiel Elliott, Michael Thomas and Melvin Gordon are among the players who have not reported for training camp so far.
The no-call cost the Saints a shot at reaching Super Bowl LIII and completely overshadowed the outcome of the game.
Saints' coach Sean Payton said his team might "never get over" the incident.
The dog was unharmed but Kirsten J. Gaskins was arrested on charges of assault, harassment and cruelty to animals.
Championship Sunday sees the Rams travel to New Orleans, while the Chiefs host the New England Patriots.
The Houston Texans and the Seattle Seahawks will be in the postseason, but Pittsburgh's season is almost over.
The Saints can win the NFC for the first time in nine years, while the Seahawks and Ravens can secure wild-card spots.
Brees has averaged just under 180 passing yards over the last three games as the Saints have struggled offensively.
The Bears have a first NFC North title in eight years, while the Chargers are back in the playoffs for the first time since 2013.
The Chiefs have been one of the teams of the season and lead the AFC with an 11-3 record.
The Saints, Rams and Chiefs can all secure first round-byes, while the Patriots and Texans can win divisional titles.
The Saints, Rams and Chiefs have clinched a playoff spot, but the Patriots and Texans have to wait until at least next week.
The incident reignited the debate over whether the NFL wants to stamp out helmet-to-helmet collisions.
The Cowboys halted the Saints' 10-game winning run with a surprise 13-10 on TNF.
One of the NFL's dearest traditions resumes as the Lions and Cowboys play on Turkey Day.
The incident will put the NFL under further pressure to review its stance over cheerleaders.
Bailey Davis, 22, claims the Saints are guilty of double standards in rules for male and female employees.
The market is likely to be quarterback-friendly.
Has there ever been a better finish to a divisional playoff game?
There are questions about whether Newton was checked out thoroughly enough.