The 49ers are off to their best start in almost three decades, while the Packers and the Saints look nailed-on to reach the playoffs.
The Cowboys are 3-0 for the first time in 11 years and will look to lay down a marker in New Orleans against the Saints.
Week 4 of the NFL regular season kicks off on Thursday when the Philadelphia Eagles travel to Green Bay to face the Packers.
The veteran signal caller was injured on Sunday in the loss against the Los Angeles Rams and is expected to be out for six weeks.
The veteran quarterback was replaced in the first quarter with a thumb injury and will see a hand specialist in Los Angeles.
Seth Dunlap, host of New Orleans station WWL-AM's "The Last Lap," wrote an essay about the recent controversy over Saints quarterback Drew Brees' relationship with Focus on the Family.
The Patriots travel to Miami in what could be a hopelessly lopsided game, while Cleveland must turn things around on Monday night on the road against the Jets.
The Steelers begin their defense of the NFC South title when they take on the Texans in New Orleans Monday night.
Six games will be nationally broadcast in Week 3 of preseason, beginning with the Jacksonville Jaguars' trip to Miami on Thursday night.
Both the Saints and the Chargers lost their first preseason games and will be looking to bounce back on Sunday.
The New England Patriots and the Kansas City Chiefs are the bookmakers' favorites, followed by the Los Angeles Rams and the New Orleans Saints.
Week 1 of the NFL season sees the New Orleans Saints hosting the Houston Texans and the Oakland Raiders welcoming the Denver Broncos.
Ezekiel Elliott, Michael Thomas and Melvin Gordon are among the players who have not reported for training camp so far.
The no-call cost the Saints a shot at reaching Super Bowl LIII and completely overshadowed the outcome of the game.
Saints' coach Sean Payton said his team might "never get over" the incident.
The dog was unharmed but Kirsten J. Gaskins was arrested on charges of assault, harassment and cruelty to animals.
Championship Sunday sees the Rams travel to New Orleans, while the Chiefs host the New England Patriots.
The Houston Texans and the Seattle Seahawks will be in the postseason, but Pittsburgh's season is almost over.
The Saints can win the NFC for the first time in nine years, while the Seahawks and Ravens can secure wild-card spots.
Brees has averaged just under 180 passing yards over the last three games as the Saints have struggled offensively.
The Bears have a first NFC North title in eight years, while the Chargers are back in the playoffs for the first time since 2013.
The Chiefs have been one of the teams of the season and lead the AFC with an 11-3 record.
The Saints, Rams and Chiefs can all secure first round-byes, while the Patriots and Texans can win divisional titles.
The Saints, Rams and Chiefs have clinched a playoff spot, but the Patriots and Texans have to wait until at least next week.
The incident reignited the debate over whether the NFL wants to stamp out helmet-to-helmet collisions.