Mauricio Pochettino's men look for a second home win of the season on Sunday and could deepen Newcastle's woes.
After spending big in the summer, Arsenal kicks off its Premier League campaign against Newcastle on Sunday.
Another summer of upheaval is closing in.
Premier League teams are already making summer plans.
Owner Mike Ashley wants to sell after 10 years in charge.
Rafael Benitez's Newcastle United is the visitor to Old Trafford on Saturday.
Newcastle was promoted to the Premier League on Monday.
Moussa Sissoko has spoken of his support for Arsene Wenger's club.
It seemed unlikely initially, but talks have progressed well.
Leicester may have triumphed ahead of time, but there's plenty of interest left on show.
The Manchester City forward is the second fastest to reach the milestone after Alan Shearer.
The Lyons striker's reported move to Newcastle United would be logical despite the club's Premier League plight.